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Either mutations or deletions in the survival of motoneuron\n                    <jats:italic>(SMN<\/jats:italic>\n                    ) gene are responsible for this defect. SMN is an assembly protein for RNA\u2010protein complexes in the nucleus and is also found in axons of neurons. However, it is unclear which dysfunctions of SMN are important for disease progression. In this study we analyzed the contributions of different SMN regions for localization and neuronal differentiation associated with outgrowth of neurites. Suppression of endogenous SMN protein levels significantly decreased the growth of neurites. Down\u2010regulation of the interacting protein gemin2 had the opposite effect. Surprisingly, selective overexpression of the SMN C\u2010terminal domain promoted neurite outgrowth similar to full\u2010length protein and could rescue the SMN knock\u2010down effects. The knock\u2010down led to a significant change in the G\u2010\/F\u2010actin ratio, indicating a role for SMN in actin dynamics. Therefore, our data suggest a functional role for SMN in microfilament metabolism in axons of motoneurons.\u2014van Bergeijk, J., Rydel\u2010K\u00f6necke, K., Grothe, C., Claus, P. The spinal muscular atrophy gene product regulates neurite outgrowth: importance of the C terminus.\n                    <jats:italic>FASEB J.<\/jats:italic>\n                    21, 1492\u20131502 (2007)\n                  <\/jats:p>","DOI":"10.1096\/fj.06-7136com","type":"journal-article","created":{"date-parts":[[2007,2,22]],"date-time":"2007-02-22T20:36:27Z","timestamp":1172176587000},"page":"1492-1502","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["The spinal muscular atrophy gene product regulates neurite outgrowth: importance of the C terminus"],"prefix":"10.1096","volume":"21","author":[{"given":"Jeroen","family":"van Bergeijk","sequence":"first","affiliation":[{"name":"Department of Neuroanatomy Hannover Medical School Center for Systems Neuroscience (ZSN) Hannover Hannover 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