{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T07:37:18Z","timestamp":1778657838027,"version":"3.51.4"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,1,16]],"date-time":"2007-01-16T00:00:00Z","timestamp":1168905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2007,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The treatment of dyspeptic disorders with anti\u2010acids leads to an increased risk of sensitization against food allergens. As these drugs are taken by 30\u201350% of pregnant women due to reflux and heartburn, we aimed here to investigate the impact of maternal therapy with anti\u2010acids on the immune response in the offspring in a murine model. Codfish extract as model allergen was fed with or without sucralfate, an anti\u2010acid drug, to pregnant BALB\/c mice during pregnancy and lactation. These mothers developed a codfish\u2010specific allergic response shown as high IgG1 and IgE antibody levels and positive skin tests. In the next step we analyzed whether this maternal sensi\u2010tization impacts a subsequent sensitization in the offspring. Indeed, in stimulated splenocytes of these off\u2010spring we found a relative Th2\u2010dominance, because the Thl\u2010 and T\u2010regulatory cytokines were significantly sup\u2010pressed. Our data provide evidence that the anti\u2010acid drug sucralfate supports sensitization against food in pregnant mice and favors a Th2\u2010milieu in their offspring. From these results we propose that anti\u2010acid treatment during pregnancy could be responsible for the increasing number of sensitizations against food allergens in young infants.\u2014Sch\u00f6ll, I., Ackermann, U., \u00d6zdemir, C., Bl\u00fcmer, N., Dicke, T., Sel, S., Sel, S., Wegmann, M., Szalai, K., Knittelfelder, R., Untersmayr, E., Scheiner, O., Garn, H., Jensen\u2010Jarolim, E., Renz, H. Anti\u2010ulcer treatment during pregnancy induces food allergy in mouse mothers and a Th2\u2010bias in their offspring.\n                    <jats:italic>FASEB J.<\/jats:italic>\n                    21, 1264\u20131270 (2007)\n                  <\/jats:p>","DOI":"10.1096\/fj.06-7223com","type":"journal-article","created":{"date-parts":[[2007,1,16]],"date-time":"2007-01-16T22:18:59Z","timestamp":1168985939000},"page":"1264-1270","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":66,"title":["Anti\u2010ulcer treatment during pregnancy induces food allergy in mouse mothers and a Th2\u2010bias in their offspring"],"prefix":"10.1096","volume":"21","author":[{"given":"Isabella","family":"Sch\u00f6ll","sequence":"first","affiliation":[{"name":"Department of Pathophysiology Medical University of Vienna Vienna 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