{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T12:39:20Z","timestamp":1782304760653,"version":"3.54.5"},"reference-count":38,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2007,2,22]],"date-time":"2007-02-22T00:00:00Z","timestamp":1172102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RO\u20101 HL\u201055627"],"award-info":[{"award-number":["RO\u20101 HL\u201055627"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Cigarette smoking affects all phases of atherosclerosis from endothelial dysfunction to acute occlusive clinical events. We explored activation by exposure to tobacco smoke of two genes, \u03b2\u2010catenin and COX\u20102, that play key roles in inflammation and vascular remodeling events. Using both\n                    <jats:italic>in vivo<\/jats:italic>\n                    and\n                    <jats:italic>in vitro<\/jats:italic>\n                    smoke exposure, we determined that tobacco smoke (TS) induced nuclear \u03b2\u2010catenin accumulation and COX\u20102 expression and activity and moreover interacted with IL\u20101\u03b2 to enhance these effects. Exposure of cardiac endothelial cells to tobacco smoke plus IL\u20101\u03b2 (TS\/IL\u20101\u03b2 ) enhanced permeability of endothelial monolayers and disrupted membrane VE\u2010cadherin\/\u03b2\u2010catenin complexes, decreased \u03b2\u2010catenin phosphoryla\u2010tion, and increased phosphorylation of GSK\u20103\u03b2, Akt, and EGFR. Transfection of endothelial cells with \u03b2\u2010catenin\u2010directed small interferring RNA (siRNA) suppressed TS\/IL\u20101\u03b2\u2010mediated effects on COX\u20102 modulation. Inhibitors of EGFR and phosphatidylinositol\u20103\u2010kinase also abolished both the TS\/IL\u20101\u03b2\u2010mediated modulation of the Akt\/GSK\u20103\u03b2\/\u03b2\u2010catenin pathway and enhancement of COX\u20102 expression. Moreover, increased levels of Akt and GSK\u20103\u03b2 phosphorylation, nuclear \u03b2\u2010catenin accumulation, COX\u20102 expression, and IL\u20101\u03b2 were observed in cardiovascular tissue of ApoE\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice exposed to cigarette smoke daily for 2 wk. Our results suggest a novel mechanism by which cigarette smoking can induce proinflammatory and proatherosclerotic effects in vascular tissue.\u2014Barbieri S. S., Weksler B. B. Tobacco smoke cooperates with interleukin\u20101 \u03b2 to alter \u03b2\u2010catenin trafficking in vascular endothelium resulting in increased permeability and induction of cyclooxygenase\u20102 expression in vitro and in vivo.\n                    <jats:italic>FASEB J.<\/jats:italic>\n                    21, 1831\u20131843 (2007)\n                  <\/jats:p>","DOI":"10.1096\/fj.06-7557com","type":"journal-article","created":{"date-parts":[[2007,2,22]],"date-time":"2007-02-22T20:36:27Z","timestamp":1172176587000},"page":"1831-1843","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":78,"title":["Tobacco smoke cooperates with interleukin\u20101\u03b2 to alter \u03b2\u2010catenin trafficking in vascular endothelium resulting in increased permeability and induction of cyclooxygenase\u20102 expression\n                    <i>in vitro<\/i>\n                    and\n                    <i>in vivo<\/i>"],"prefix":"10.1096","volume":"21","author":[{"given":"Silvia S.","family":"Barbieri","sequence":"first","affiliation":[{"name":"Division of Hematology\u2010Medical Oncology Weill Medical College of Cornell University New York New York USA"},{"name":"Department of Pharmacological Sciences University of Milan Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Babette B.","family":"Weksler","sequence":"additional","affiliation":[{"name":"Division of Hematology\u2010Medical Oncology Weill Medical College of Cornell University New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,2,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2003.12.047"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000193510.19000.10"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1997.tb51989.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1078-5884(03)00342-3"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.280.5363.596"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.10.5522"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.281.5382.1509"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(02)00824-0"},{"key":"e_1_2_6_10_1","first-page":"728","article-title":"Regulation of cyclooxygenase\u20102 expression by the Wnt and ras pathways","volume":"63","author":"Araki Y.","year":"2003","journal-title":"Cancer Res."},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1208296"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-004-0213-y"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.52.33157"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1053\/ejvs.2000.1145"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.12.12.1063"},{"key":"e_1_2_6_16_1","first-page":"2816","article-title":"A simple method of vascular endothelial cell isolation","volume":"24","author":"Lodge P. 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