{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T15:49:35Z","timestamp":1779896975795,"version":"3.53.1"},"reference-count":31,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2007,4,20]],"date-time":"2007-04-20T00:00:00Z","timestamp":1177027200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2007,4,20]],"date-time":"2007-04-20T00:00:00Z","timestamp":1177027200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK61846"],"award-info":[{"award-number":["DK61846"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL073742"],"award-info":[{"award-number":["HL073742"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1K08HL079066"],"award-info":[{"award-number":["1K08HL079066"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2007,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Cell fusion is one mechanism by which bone marrow\u2010derived cells (BMDCs) take on the gene expression pattern of nonhematopoietic cells. This process occurs in a number of organs with posten\u2010graftment injury but has never been found in the lung. We performed bone marrow (BM) transplant in a murine model of lung inflammation to test whether transplanted BMDCs develop lung\u2010specific gene expression by fusing with diseased pneumocytes. Mice lacking the lung\u2010specific protein surfactant protein C (Sp\u2010C) were lethally irradiated, transplanted with sex mismatched wild\u2010type marrow, and sacrificed 6 months later. Nineteen\/38 recipients exhibited Sp\u2010C mRNA (RT\u2010PCR) and\/or protein (mean 0.95\u00b11.18 Sp\u2010C+ cells per 1000 type II pneumocytes by confo\u2010cal microscopy). In male recipients of female BM, 65% of Sp\u2010C + cells contained the Y chromosome, indicating their origin from fusion. Only 28% of Sp\u2010C+ cells in female recipients of male BMDCs contained the Y chromosome, suggesting that 72% of Sp\u2010C\u2010expressing cells lost the Y chromosome. In the setting of post\u2010transplant inflammation, pneumocyte\u2010specific reprogramming of transplanted BMDCs predominantly derives from heterokaryon formation. This process does not reverse inflammation caused by Sp\u2010C deficiency;nevertheless, further investigation may identify phenotypes benefiting from such an approach.\u2014Herzog, E. L., Van Arnam, J., Hu, B., Zhang, J., Chen, Q., Haberman, A. M., Krause, D. S. Lung\u2010specific nuclear reprogramming is accompanied by heterokaryon formation and Y chromosome loss following bone marrow transplantation and secondary inflammation.\n                    <jats:italic>FASEB J.<\/jats:italic>\n                    21, 2592\u20132601 (2007)\n                  <\/jats:p>","DOI":"10.1096\/fj.06-7861com","type":"journal-article","created":{"date-parts":[[2007,4,20]],"date-time":"2007-04-20T21:00:13Z","timestamp":1177102813000},"page":"2592-2601","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Lung\u2010specific nuclear reprogramming is accompanied by heterokaryon formation and Y chromosome loss following bone marrow transplantation and secondary inflammation"],"prefix":"10.1096","volume":"21","author":[{"given":"Erica L.","family":"Herzog","sequence":"first","affiliation":[{"name":"Departments of Internal Medicine Yale University School of Medicine New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Van Arnam","sequence":"additional","affiliation":[{"name":"Departments of Laboratory Medicine Yale University School of Medicine New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Buqu","family":"Hu","sequence":"additional","affiliation":[{"name":"Departments of Laboratory Medicine Yale University School of Medicine New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Zhang","sequence":"additional","affiliation":[{"name":"Departments of Laboratory Medicine Yale University School of Medicine New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingsheng","family":"Chen","sequence":"additional","affiliation":[{"name":"Departments of Internal Medicine Yale University School of Medicine New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann M.","family":"Haberman","sequence":"additional","affiliation":[{"name":"Departments of Immunobiology Yale University School of Medicine New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane S.","family":"Krause","sequence":"additional","affiliation":[{"name":"Departments of Laboratory Medicine Yale University School of Medicine New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,4,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-05-1664"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1053"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature02069"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01531"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01539"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200506123"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0508593103"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2005.09.004"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1098925"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2005-0579"},{"key":"e_1_2_6_12_1","article-title":"Radiation pneumonitis in mice: a severe injurymodel for pneumocyte engraftment from bone marrow","author":"Theise N. 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