{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T20:38:37Z","timestamp":1791923917250,"version":"4.3.4"},"reference-count":36,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2007,3,23]],"date-time":"2007-03-23T00:00:00Z","timestamp":1174608000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2007,3,23]],"date-time":"2007-03-23T00:00:00Z","timestamp":1174608000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2007,7]]},"abstract":"<jats:p>\n                    In addition to their role in controlling water and salt homeostasis, recent work suggests that aldosterone and mineralocorticoid receptors (MR) may be involved in adipocyte biology. This is of particular relevance given the role of MR as a high\u2010affinity receptor for both mineralocorticoids and glucocorticoids. We have thus examined the effect of aldosterone and MR on white adipose cell differentiation. When cells are cultured in a steroid\u2010free medium, aldosterone promotes acquisition of the adipose phenotype of 3T3\u2010L1 and 3T3\u2010F442A cells in a time\u2010, dose\u2010, and MR\u2010dependent manner. In contrast, late and long\u2010term exposure to dexamethasone inhibits adipocyte terminal maturation. The aldosterone effect on adipose maturation was accompanied by induction of PPAR\u03b3 mRNA expression, which was blocked by the MR antagonist spironolactone. Under permissive culture conditions, specific MR down\u2010regulation by siRNAs markedly inhibited 3T3\u2010L1 differentiation by interfering with the transcriptional control of adipogenesis, an effect not mimicked by specific inactivation of the glucocorticoid receptor. These results demonstrate that MR represents an important proadipogenic transcription factor that may mediate both aldosterone and glucocorticoid effects on adipose tissue development. MR thus may be of pathophysiological relevance to the development of obesity and the metabolic syndrome.\u2013Caprio, M., F\u00e8ve, B., Cla\u00ebs, A., Viengchareun, S., Lomb\u00e8s, M., Zennaro, M\u2010C. Pivotal role of the mineralocorticoid receptor in corticosteroid\u2010induced adipogenesis.\n                    <jats:italic>FASEB J.<\/jats:italic>\n                    21, 2185\u20132194 (2007)\n                  <\/jats:p>","DOI":"10.1096\/fj.06-7970com","type":"journal-article","created":{"date-parts":[[2007,3,23]],"date-time":"2007-03-23T20:38:15Z","timestamp":1174682295000},"page":"2185-2194","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":293,"title":["Pivotal role of the mineralocorticoid receptor in corticosteroid\u2010induced adipogenesis"],"prefix":"10.1096","volume":"21","author":[{"given":"Massimiliano","family":"Caprio","sequence":"first","affiliation":[{"name":"INSERM, U772 Paris France"},{"name":"Coll\u00e8ge de France Paris France"},{"name":"Department of Internal Medicine Chair of Endocrinology University Tor Vergata Rome Italy"},{"name":"IRCCS San Raffaele Pisana Via della Pisana 235 00163 Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"F\u00e8ve","sequence":"additional","affiliation":[{"name":"INSERM, U693 Facult\u00e9de M\u00e9decine Paris\u2010Sud Le Kremlin Bic\u00eatre France"},{"name":"University Paris\u2010Sud Orsay France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lie","family":"Cla\u00ebs","sequence":"additional","affiliation":[{"name":"INSERM, U772 Paris France"},{"name":"Coll\u00e8ge de France Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Say","family":"Viengchareun","sequence":"additional","affiliation":[{"name":"INSERM, U693 Facult\u00e9de M\u00e9decine Paris\u2010Sud Le Kremlin Bic\u00eatre France"},{"name":"University Paris\u2010Sud Orsay France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Lomb\u00e8s","sequence":"additional","affiliation":[{"name":"INSERM, U693 Facult\u00e9de M\u00e9decine Paris\u2010Sud Le Kremlin Bic\u00eatre France"},{"name":"University Paris\u2010Sud Orsay France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria-Christina","family":"Zennaro","sequence":"additional","affiliation":[{"name":"INSERM, U772 Paris France"},{"name":"Coll\u00e8ge de France Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,3,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1998.78.3.783"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1066285"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68699-6"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.53.4.931"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.4.1023"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-005-2344-2"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3037703"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI1915"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.2000.279.2.E386"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.2001.280.4.E640"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114345"},{"key":"e_1_2_6_13_1","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.1210\/endo.132.6.8504747","article-title":"Aldosterone stimulates differentiation of mouse 3T3-L1 cells into adipocytes","volume":"132","author":"Rondinone C. 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