{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T15:22:44Z","timestamp":1790608964419,"version":"4.1.0"},"reference-count":63,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2008,7,2]],"date-time":"2008-07-02T00:00:00Z","timestamp":1214956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2008,10]]},"abstract":"<jats:p>\n                    We had previously shown that both locally produced endocannabinoids and exocannabinoids,\n                    <jats:italic>via<\/jats:italic>\n                    cannabinoid receptor\u20101 (CB1), are powerful inhibitors of human hair growth. To further investigate the role of the cannabinoid system in pilosebaceous unit biology, we have explored in the current study whether and how endocannabinoids have an impact on human sebaceous gland biology, using human SZ95 sebocytes as cell culture model. Here, we provide the first evidence that SZ95 sebocytes express CB2 but not CB1. Also, prototypic endocannabinoids (arachidonoyl ethanolamide\/anandamide, 2\u2010arachidonoyl glycerol) are present in SZ95 sebocytes and dose\u2010dependently induce lipid production and (chiefly apoptosis\u2010driven) cell death. Endocannabinoids also up\u2010regulate the expression of key genes involved in lipid synthesis (\n                    <jats:italic>e.g.<\/jats:italic>\n                    , PPAR transcription factors and some of their target genes). These actions are selectively mediated by CB2\u2010coupled signaling involving the MAPK pathway, as revealed by specific agonists\/antagonists and by RNA interference. Because cells with \u201csilenced\u201d CB2 exhibited significantly suppressed basal lipid production, our results collectively suggest that human sebocytes utilize a paracrine\u2010autocrine, endogenously active, CB2\u2010mediated endocannabinoid signaling system for positively regulating lipid production and cell death. CB2 antagonists or agonists therefore deserve to be explored in the management of skin disorders characterized by sebaceous gland dysfunctions (\n                    <jats:italic>e.g.<\/jats:italic>\n                    , acne vulgaris, seborrhea, dry skin).\u2014Dobrosi, N., T\u00f3th, B. I., Nagy, G., D\u00f3zsa, A., G\u00e9czy, T., Nagy, L., Zouboulis, C. C., Paus, R., Kov\u00e1cs, L., B\u00edr\u00f3, T. Endocannabinoids enhance lipid synthesis and apoptosis of human sebocytes via cannabinoid receptor\u20102\u2010mediated signaling.\n                    <jats:italic>FASEB J.<\/jats:italic>\n                    22, 3685\u20133695 (2008)\n                  <\/jats:p>","DOI":"10.1096\/fj.07-104877","type":"journal-article","created":{"date-parts":[[2008,7,2]],"date-time":"2008-07-02T21:07:17Z","timestamp":1215032837000},"page":"3685-3695","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":134,"title":["Endocannabinoids enhance lipid synthesis and apoptosis of human sebocytes\n                    <i>via<\/i>\n                    cannabinoid receptor\u20102\u2010mediated signaling"],"prefix":"10.1096","volume":"22","author":[{"given":"N\u00f3ra","family":"Dobrosi","sequence":"first","affiliation":[{"name":"Department of Physiology University of Debrecen, Medical and Health Science Center, Research Center for Molecular Medicine Debrecen Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bal\u00e1zs I.","family":"T\u00f3th","sequence":"additional","affiliation":[{"name":"Department of Physiology University of Debrecen, Medical and Health Science Center, Research Center for Molecular Medicine Debrecen Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgina","family":"Nagy","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Debrecen, Medical and Health Science Center, Research Center for Molecular Medicine Debrecen Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anik\u00f3","family":"D\u00f3zsa","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology University of Debrecen, Medical and Health Science Center, Research Center for Molecular Medicine Debrecen Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tam\u00e1s","family":"G\u00e9czy","sequence":"additional","affiliation":[{"name":"Department of Physiology University of Debrecen, Medical and Health Science Center, Research Center for Molecular Medicine Debrecen Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e1szl\u00f3","family":"Nagy","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology University of Debrecen, Medical and Health Science Center, Research Center for Molecular Medicine Debrecen Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christos C.","family":"Zouboulis","sequence":"additional","affiliation":[{"name":"Departments of Dermatology Venereology, Allergology, and Immunology, Dessau Medical Center Dessau Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Paus","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Schleswig\u2010Holstein, University of L\u00fcbeck L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e1szl\u00f3","family":"Kov\u00e1cs","sequence":"additional","affiliation":[{"name":"Department of Physiology University of Debrecen, Medical and Health Science Center, Research Center for Molecular Medicine Debrecen Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tam\u00e1s","family":"B\u00edr\u00f3","sequence":"additional","affiliation":[{"name":"Department of Physiology University of Debrecen, Medical and Health Science Center, Research Center for Molecular Medicine Debrecen Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,7,2]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"7712","article-title":"The endocannabinoid system and its therapeutic exploitation","volume":"3","author":"Di Marzo V.","year":"2004","journal-title":"Nat. Rev. Drug Discov."},{"key":"e_1_2_6_3_1","first-page":"672","article-title":"The endocannabinoid system: a drug discovery perspective","volume":"6","author":"Piomelli D.","year":"2005","journal-title":"Curr. Opin. Investig. Drugs"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.58.3.2"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-09-03326.2002"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00004.2003"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2006.01.008"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/3-540-26573-2_20"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2007.08.008"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0707486"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M303994200"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0409888102"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2005.01.007"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M707964200"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0707569"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200316116"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.06-6638fje"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1142265"},{"key":"e_1_2_6_19_1","doi-asserted-by":"crossref","first-page":"3534","DOI":"10.1096\/fj.06-7689com","article-title":"Inhibition of human hair follicle growth by endo\u2010 and exocannabinoids","volume":"13","author":"Telek A.","year":"2007","journal-title":"FASEB J."},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199908123410706"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2003.12263.x"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1159\/000017861"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s007950100002"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2004.00254.x"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0906-6705.2005.0285a.x"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1999.00771.x"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.102180999"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2007-0651"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.06-7451com"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)62320-6"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2004.23209.x"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(00)01223-0"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/0-306-47611-8_27"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V91.4.1332"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-007-0209-y"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2003.12029.x"},{"key":"e_1_2_6_37_1","first-page":"A68","article-title":"The vanilloid receptor 1 (TRPV1) is expressed and functionally active on human SZ95 sebocytes","volume":"124","author":"T\u00f3th I. B.","year":"2005","journal-title":"J. Invest. Dermatol."},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-005-0715-8"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-004-4014-2"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.281.5381.1309"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/28393"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4401284"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612003399347"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.fjc.0000175437.87283.f2"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-4388(02)00340-9"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2007.05521.x"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.59.1.9"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-06-02371.2003"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2007.04642.x"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2008.01.010"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.20.5.649"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/35013000"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/83336"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-06-096222"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0707352"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0707423"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2003.12411.x"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700336"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.20.14.5343-5349.2000"},{"key":"e_1_2_6_60_1","first-page":"497","article-title":"15S\u2010Hydroxyeicosatetraenoic acid activates peroxisome proliferator\u2010activated receptor gamma and inhibits proliferation in PC3 prostate carcinoma cells","volume":"61","author":"Shappell S. B.","year":"2001","journal-title":"Cancer Res"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M108482200"},{"key":"e_1_2_6_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700028"},{"key":"e_1_2_6_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2007.06.011"},{"key":"e_1_2_6_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2007.00565.x"}],"container-title":["The FASEB Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.07-104877","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1096\/fj.07-104877","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.07-104877","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T22:57:07Z","timestamp":1761692227000},"score":1,"resource":{"primary":{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/10.1096\/fj.07-104877"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,7,2]]},"references-count":63,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2008,10]]}},"alternative-id":["10.1096\/fj.07-104877"],"URL":"https:\/\/doi.org\/10.1096\/fj.07-104877","archive":["Portico"],"relation":{},"ISSN":["0892-6638","1530-6860"],"issn-type":[{"value":"0892-6638","type":"print"},{"value":"1530-6860","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,7,2]]},"assertion":[{"value":"2007-04-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2008-06-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2008-07-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}