{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:36:53Z","timestamp":1791200213831,"version":"4.2.0"},"reference-count":23,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2007,6,5]],"date-time":"2007-06-05T00:00:00Z","timestamp":1181001600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5K01DK070007"],"award-info":[{"award-number":["5K01DK070007"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["DEB\u2010021306"],"award-info":[{"award-number":["DEB\u2010021306"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["DEB\u20100445351"],"award-info":[{"award-number":["DEB\u20100445351"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2007,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The effects of nonmutagenic environmental exposures can sometimes be transmitted for several generations, suggesting transgenerational inheritance of induced epigenetic variation. Methyl donor supplementation of female mice during pregnancy induces CpG hypermethylation at the\n                    <jats:italic>\n                      agouti viable yellow (A\n                      <jats:sup>vy<\/jats:sup>\n                      )\n                    <\/jats:italic>\n                    allele in\n                    <jats:italic>\n                      A\n                      <jats:sup>vy<\/jats:sup>\n                      \/a\n                    <\/jats:italic>\n                    offspring. Epigenetic inheritance occurs at\n                    <jats:italic>\n                      A\n                      <jats:sup>vy<\/jats:sup>\n                      ;\n                    <\/jats:italic>\n                    when passed through the female germ line,\n                    <jats:italic>\n                      A\n                      <jats:sup>vy<\/jats:sup>\n                    <\/jats:italic>\n                    epigenotype is not completely \u201creset.\u201d We therefore tested whether diet\u2010induced epigenetic alterations at\n                    <jats:italic>\n                      A\n                      <jats:sup>vy<\/jats:sup>\n                    <\/jats:italic>\n                    are inherited transgenerationally. Female\n                    <jats:italic>\n                      A\n                      <jats:sup>vy<\/jats:sup>\n                      \/a\n                    <\/jats:italic>\n                    mice were weaned onto either control (\n                    <jats:italic>n<\/jats:italic>\n                    =6) or a methyl\u2010supplemented diet (\n                    <jats:italic>n<\/jats:italic>\n                    =5). These F0 dams were mated with\n                    <jats:italic>a\/a<\/jats:italic>\n                    males. All F1 and F2\n                    <jats:italic>\n                      A\n                      <jats:sup>vy<\/jats:sup>\n                      \/a\n                    <\/jats:italic>\n                    females were weaned onto the same diet as their mothers, then mated with\n                    <jats:italic>a\/a<\/jats:italic>\n                    males. F1, F2, and F3\n                    <jats:italic>\n                      A\n                      <jats:sup>vy<\/jats:sup>\n                      \/a\n                    <\/jats:italic>\n                    offspring were classified for coat color, an indicator of\n                    <jats:italic>\n                      A\n                      <jats:sup>vy<\/jats:sup>\n                    <\/jats:italic>\n                    methylation. In total, 62 F1, 98 F2, and 209 F3\n                    <jats:italic>\n                      A\n                      <jats:sup>vy<\/jats:sup>\n                      \/a\n                    <\/jats:italic>\n                    mice were studied. As expected, average\n                    <jats:italic>\n                      A\n                      <jats:sup>vy<\/jats:sup>\n                      \/a\n                    <\/jats:italic>\n                    coat color was darker in the supplemented group (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.01). However, there was no cumulative effect of supplementation across successive generations. These results suggest that, in the female germ line, diet\u2010induced\n                    <jats:italic>\n                      A\n                      <jats:sup>vy<\/jats:sup>\n                    <\/jats:italic>\n                    hypermethylation occurs in the absence of additional epigenetic modifications that normally confer transgen\u2010erational epigenetic inheritance at the locus.\u2014Waterland R. A., Travisano, M., Tahiliani K. G. Diet\u2010induced hypermethylation at agouti viable yellow is not inherited transgenerationally through the female.\n                    <jats:italic>FASEB J.<\/jats:italic>\n                    21, 3380\u20133385 (2007)\n                  <\/jats:p>","DOI":"10.1096\/fj.07-8229com","type":"journal-article","created":{"date-parts":[[2007,6,5]],"date-time":"2007-06-05T22:19:00Z","timestamp":1181081940000},"page":"3380-3385","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":172,"title":["Diet\u2010induced hypermethylation at\n                    <i>agouti viable yellow<\/i>\n                    is not inherited transgenerationally through the female"],"prefix":"10.1096","volume":"21","author":[{"given":"Robert A.","family":"Waterland","sequence":"first","affiliation":[{"name":"Departments of Pediatrics and Molecular and Human Genetics Baylor College of Medicine USDA Children\u2032s Nutrition Research Center Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Travisano","sequence":"additional","affiliation":[{"name":"Department of Biology and Biochemistry University of Houston Houston Texas USA"},{"name":"Department of Ecology, Evolution and Behavior University of Minnesota St. Paul Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kajal G.","family":"Tahiliani","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics and Molecular and Human Genetics Baylor College of Medicine USDA Children\u2032s Nutrition Research Center Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,6,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1089"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gde.2004.09.001"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg1834"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1063443"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gde.2006.09.002"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(71)90102-8"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1108190"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5200859"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5201538"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5200901"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.119.3.933"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(06)00124-2"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0994-59"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-9525(02)02709-9"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.12.11.949"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/15490"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.23.15.5293-5300.2003"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0607090103"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.0020049"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1006\/faat.1996.0019"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddi484"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/gene.10168"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvg.20230"}],"container-title":["The 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