{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T14:15:03Z","timestamp":1770819303437,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2007,5,18]],"date-time":"2007-05-18T00:00:00Z","timestamp":1179446400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000901","name":"Juvenile Diabetes Research Foundation International","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2007,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    We have previously identified ligands from combinatorial peptide libraries that target tumor vasculature after\n                    <jats:italic>in vivo<\/jats:italic>\n                    selection. These ligands bind to differentially expressed receptors in angiogenic vascu\u2010lature such as \u03b1\n                    <jats:sub>v<\/jats:sub>\n                    \u03b2\n                    <jats:sub>3<\/jats:sub>\n                    \/\u03b1\n                    <jats:sub>v<\/jats:sub>\n                    \u03b2\n                    <jats:sub>5<\/jats:sub>\n                    integrins, aminopeptidase N, and aminopeptidase A. We hypothesized that we can use these ligands to target angiogenic vasculature in retinopathies. Pathological retinal angiogenesis in conditions such as diabetic retinopathy, retinopathy of prematurity, and age\u2010related macular degeneration is a major cause of blindness for which current treatments are inadequate. Here we tested whether known tumor vasculature targeting peptide ligands displayed on bac\u2010teriophage particles would home to the proliferating blood vessels of the retina in a standard mouse model of retinopathy of prematurity. We found that activated retinal blood vessels share many of the endothelial and periendothelial cell receptors expressed in tumor vas\u2010culature. Furthermore, these vascular receptors\u2014\u03b1\n                    <jats:sub>v<\/jats:sub>\n                    integrins and aminopeptidases\u2014are accessible through the circulation and mediate phage homing and internal\u2010ization to endothelial and periendothelial cells. Treatment of mice with a peptide containing a \u03b1\n                    <jats:sub>v<\/jats:sub>\n                    \u03b2\n                    <jats:sub>3<\/jats:sub>\n                    \/\u03b1\n                    <jats:sub>v<\/jats:sub>\n                    \u03b2\n                    <jats:sub>5<\/jats:sub>\n                    \u2010integrin targeting domain fused to a proapoptotic domain significantly reduced oxygen\u2010induced retinal angiogenesis by selectively inducing activated endothe\u2010lial cell apoptosis. Targeted proapoptotic peptides may prove useful in the management of angiogenic retinal diseases.\u2014Lahdenranta J., Sidman, R. L., Pasqualini, R., Arap W. Treatment of hypoxia\u2010induced retinopathy with targeted proapoptotic peptidomimetic in a mouse model of disease.\n                    <jats:italic>FASEB J.<\/jats:italic>\n                    21, 3272\u20133278 (2007)\n                  <\/jats:p>","DOI":"10.1096\/fj.07-8273com","type":"journal-article","created":{"date-parts":[[2007,5,19]],"date-time":"2007-05-19T10:51:44Z","timestamp":1179571904000},"page":"3272-3278","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Treatment of hypoxia\u2010induced retinopathy with targeted proapoptotic peptidomimetic in a mouse model of disease"],"prefix":"10.1096","volume":"21","author":[{"given":"Johanna","family":"Lahdenranta","sequence":"first","affiliation":[{"name":"The University of Texas M. D. Anderson Cancer Center Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard L.","family":"Sidman","sequence":"additional","affiliation":[{"name":"Harvard Medical School and Department of Neurology Beth Israel Deaconess Medical Center Harvard Institutes of Medicine Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata","family":"Pasqualini","sequence":"additional","affiliation":[{"name":"The University of Texas M. D. Anderson Cancer Center Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wadih","family":"Arap","sequence":"additional","affiliation":[{"name":"The University of Texas M. D. 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