{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:14:13Z","timestamp":1791292453710,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2007,12,27]],"date-time":"2007-12-27T00:00:00Z","timestamp":1198713600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2008,5]]},"abstract":"<jats:p>\n                    The sense of taste informs the body about the quality of ingested foods. Tastant\u2010mediated signals are generated by a rise in free intracellular calcium levels ([Ca\n                    <jats:sup>2+<\/jats:sup>\n                    ]i) in the taste bud cells and then are transferred to the gustatory area of brain\n                    <jats:italic>via<\/jats:italic>\n                    connections between the gustatory nerves (chorda tym\u2010 pani and glossopharyngeal nerves) and the nucleus of solitary tract in the brain stem. We have recently shown that lingual CD36 contributes to fat preference and early digestive secretions in the mouse. We show here that\n                    <jats:italic>1<\/jats:italic>\n                    ) the induction of an increase in [Ca\n                    <jats:sup>2+<\/jats:sup>\n                    ]i by linoleic acid is CD36\u2010dependent in taste receptor cells, 2) the spontaneous preference for or conversely con ditioned aversion to linoleic acid requires intact gusta tory nerves, and\n                    <jats:italic>3)<\/jats:italic>\n                    the activation of gustatory neurons in the nucleus of the solitary tract elicited by a linoleic acid deposition on the tongue in wild\u2010type mice cannot be reproduced in CD36\u2010null animals. We conclude that the CD36\u2010mediated perception of long\u2010chain fatty acids involves the gustatory pathway, suggesting that the mouse may have a \u201ctaste\u201c for fatty foods. This system would constitute a potential physiological advantage under conditions of food scarcity by leading the mouse to select and absorb fatty foods. However, it might also lead to a risk of obesity and associated diseases in a context of constantly abundant food.\u2014Gaillard, D., Laugerette, F., Darcel, N., El\u2010Yassimi, A., Passilly\u2010De grace, P., Hichami, A., Khan, N. A., Montmayeur, J.\u2010P., Besnard, P. The gustatory pathway is involved in CD36\u2010 mediated orosensory perception of long\u2010chain fatty acids in the mouse.\n                    <jats:italic>FASEB J<\/jats:italic>\n                    . 22, 1458\u20131468 (2008)\n                  <\/jats:p>","DOI":"10.1096\/fj.07-8415com","type":"journal-article","created":{"date-parts":[[2007,12,27]],"date-time":"2007-12-27T20:14:21Z","timestamp":1198786461000},"page":"1458-1468","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":209,"title":["The gustatory pathway is involved in CD36\u2010mediated orosensory perception of long\u2010chain fatty acids in the mouse"],"prefix":"10.1096","volume":"22","author":[{"given":"Dany","family":"Gaillard","sequence":"first","affiliation":[{"name":"Physiologie de la Nutrition, UMR INSERM U 866, Ecole Nationale Sup\u00e9rieure de Biologie Appliqu\u00e9e \u00e0 la Nutrition et \u00e0 l'Alimentation Universit\u00e9 de Bourgogne Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabienne","family":"Laugerette","sequence":"additional","affiliation":[{"name":"Physiologie de la Nutrition, UMR INSERM U 866, Ecole Nationale Sup\u00e9rieure de Biologie Appliqu\u00e9e \u00e0 la Nutrition et \u00e0 l'Alimentation Universit\u00e9 de Bourgogne Dijon France"},{"name":"Chimior\u00e9ception, Centre Europ\u00e9en des Sciences du Go\u00fbt, UMR 5170 Centre National de la Recherche Scientifique\/1214 Institut National de la Recherche Agronomique (INRA)\/Universit\u00e9 de Bourgogne Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Darcel","sequence":"additional","affiliation":[{"name":"Physiologie de la Nutrition et du Comportement Alimentaire Institut National Agronomique Paris Grignon (INAPG), UMR 914 INRA\/INAPG Paris 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