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In the cochlea, megalin is strongly expressed within the marginal cells of the stria vascularis, and previous studies demonstrated that \u03b2\u2010estro\u2010gen receptors are also expressed in megalin\u2010expressing marginal cells. In the present study, we demonstrate that homozygous megalin mutant mice exhibit profound hearing loss at 3 months of age associated with features of presbycusis, enrichment of lipofuscin granules, and a reduced number of microvilli in marginal cells of the stria vascularis. FITC\u2010labeled \u03b2\u2010estrogen is taken up into the strial marginal cells; however, in megalin\u2010deficient mice the uptake of FITC\u2010labeled \u03b2\u2010estrogen is reduced. This highlights \u03b2\u2010estrogen as a possible carrier\u2010bound candidate ligand for megalin and supports the concept that estrogen may function\n                    <jats:italic>via<\/jats:italic>\n                    megalin within the inner ear. A crucial role of megalin in hearing should be considered and the mega\u2010lin\/estrogen interaction needs to be discussed in the context of early presbycusis in estrogen\u2010deficient humans and mice.\u2014K\u00f6nig, O., R\u00fcttiger, L., M\u00fcller, M., Zimmermann, U., Erdmann, B., Kalbacher, H., Gross, M., Knipper, M. Estrogen and the inner ear: megalin knockout mice suffer progressive hearing loss.\n                    <jats:italic>FASEB J.<\/jats:italic>\n                    22, 410\u2013417 (2008)\n                  <\/jats:p>","DOI":"10.1096\/fj.07-9171com","type":"journal-article","created":{"date-parts":[[2007,9,10]],"date-time":"2007-09-10T20:39:41Z","timestamp":1189456781000},"page":"410-417","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Estrogen and the inner ear: megalin knockout mice suffer progressive hearing loss"],"prefix":"10.1096","volume":"22","author":[{"given":"Ovidiu","family":"K\u00f6nig","sequence":"first","affiliation":[{"name":"Audiology and Phoniatry Charit\u00e9 University Clinic Berlin Campus Benjamin Franklin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"R\u00fcttiger","sequence":"additional","affiliation":[{"name":"Molecular Neurobiology and Cell Biology of the Inner Ear University of T\u00fcbingen T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Regenerative Biology Department of Otorhinolaryngology Hearing Research Center T\u00fcbingen (THRC)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike","family":"Zimmermann","sequence":"additional","affiliation":[{"name":"Molecular Neurobiology and Cell Biology of the Inner Ear University of T\u00fcbingen T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina","family":"Erdmann","sequence":"additional","affiliation":[{"name":"Electron Microscopy Max-Delbr\u00fcck-Center for Molecular Medicine Berlin-Buch Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hubert","family":"Kalbacher","sequence":"additional","affiliation":[{"name":"Medical and Natural Sciences Research Centre University of T\u00fcbingen T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manfred","family":"Gross","sequence":"additional","affiliation":[{"name":"Audiology and Phoniatry Charit\u00e9 University Clinic Berlin Campus Benjamin Franklin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlies","family":"Knipper","sequence":"additional","affiliation":[{"name":"Molecular Neurobiology and Cell Biology of the Inner Ear University of T\u00fcbingen T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,9,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2786251"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.21.9725"},{"key":"e_1_2_6_4_1","doi-asserted-by":"crossref","first-page":"3116","DOI":"10.1016\/S0021-9258(19)39742-X","article-title":"NPXY, a sequence often found in cytoplasmic tails, is required for coated pit-mediated internalization of the low density lipoprotein receptor","volume":"265","author":"Chen W. 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