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We exposed mice to either a control or a high n\u20103 PUFA diet from 2 to 12 months of age and then treated them with the neurotoxin 1\u2010methyl\u20104\u2010phenyl\u20101,2,3,6\u2010tetrahydropyridine (MPTP;140 mg\/kg in 5 days). High n\u20103 PUFA dietary consumption completely prevented the MPTP\u2010induced decrease of tyrosine hy\u2010droxylase (TH)\u2010labeled nigral cells (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.01\n                    <jats:italic>vs.<\/jats:italic>\n                    MPTP mice on control diet), Nurrl mRNA (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.01\n                    <jats:italic>vs.<\/jats:italic>\n                    MPTP mice on control diet), and dopamine transporter mRNA levels (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.05\n                    <jats:italic>vs.<\/jats:italic>\n                    MPTP mice on control diet) in the substantia nigra. Although n\u20103 PUFA dietary treatment had no effect on striatal dopaminergic terminals, the high n\u20103 PUFA diet protected against the MPTP\u2010induced decrease in dopamine (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.05\n                    <jats:italic>vs.<\/jats:italic>\n                    MPTP mice on control diet) and its metabolite dihydroxyphenylacetic acid (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.05\n                    <jats:italic>vs.<\/jats:italic>\n                    MPTP mice on control diet) in the striatum. Taken together, these data suggest that a high n\u20103 PUFA dietary intake exerts neuroprotective actions in an animal model of Parkinsonism. Bous\u2010quet M., Saint\u2010Pierre, M., Julien, C., Salem, N. Jr., Cicchetti, F., Calon F. Beneficial effects of dietary omega\u20103 polyunsaturated fatty acid on toxin\u2010induced neuronal degeneration in an animal model of Parkinson's disease. FASEB J. 22, 1213\u20131225 (2008)\n                  <\/jats:p>","DOI":"10.1096\/fj.07-9677com","type":"journal-article","created":{"date-parts":[[2007,11,21]],"date-time":"2007-11-21T21:07:32Z","timestamp":1195679252000},"page":"1213-1225","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":192,"title":["Beneficial effects of dietary omega\u20103 polyunsaturated fatty acid on toxin\u2010induced neuronal degeneration in an animal model of Parkinson's disease"],"prefix":"10.1096","volume":"22","author":[{"given":"M.","family":"Bousquet","sequence":"first","affiliation":[{"name":"Centre de Recherche en Endocrinologie Mol\u00e9culaire et Oncologique Centre Hospitalier Universitaire de Qu\u00e9bec (CHUQ) Quebec Canada"},{"name":"Faculte de pharmacie Universite Laval Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Saint\u2010Pierre","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Neurosciences Centre Hospitalier de l\u2019Universit\u00e9 Laval (CHUL) Centre Hospitalier Universitaire de Qu\u00e9bec (CHUQ) Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Julien","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Endocrinologie Mol\u00e9culaire et Oncologique Centre Hospitalier Universitaire de Qu\u00e9bec (CHUQ) Quebec Canada"},{"name":"Faculte de pharmacie Universite Laval Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"N.","family":"Salem","sequence":"additional","affiliation":[{"name":"Section of Nutritional Neuroscience Laboratory of Membrane Biochemistry and Biophysics Division of Intramural Clinical and Biological Research National Institute on Alcohol Abuse and Alcoholism Rockville Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Cicchetti","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Neurosciences Centre Hospitalier de l\u2019Universit\u00e9 Laval (CHUL) Centre Hospitalier Universitaire de Qu\u00e9bec (CHUQ) Quebec Canada"},{"name":"D\u00e9partement de M\u00e9decine Universite Laval Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Calon","sequence":"additional","affiliation":[{"name":"Centre de Recherche en Endocrinologie Mol\u00e9culaire et Oncologique Centre Hospitalier Universitaire de Qu\u00e9bec (CHUQ) Quebec Canada"},{"name":"Faculte de pharmacie Universite Laval Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,11,21]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199810083391506"},{"key":"e_1_2_5_3_1","first-page":"133","article-title":"Is the cause of Parkinson s disease environmental or hereditary? 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