{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T23:31:22Z","timestamp":1791156682545,"version":"4.1.0"},"reference-count":53,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2008,7,7]],"date-time":"2008-07-07T00:00:00Z","timestamp":1215388800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009666","name":"Salt Science Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009666","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2008,10]]},"abstract":"<jats:p>\n                    Aquaporin\u201011 (AQP11), a new member of the aquaporin family, is localized in the endoplasmic reticulum (ER).\n                    <jats:italic>Aqp11<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice neonatally suffer from polycystic kidneys derived from the proximal tubule. Its onset is proceeded by the vacuolization of ER. However, the mechanism for the formation of vacuoles and cysts remains to be clarified. Here, we show that\n                    <jats:italic>\n                      Aqp11\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    <\/jats:italic>\n                    mice and polycystic kidney disease (PKD) animals share a common pathogenic mechanism of cyst formation. We performed microarray analyses and histochemical staining to characterize the effects of the disruption of\n                    <jats:italic>Aqp11<\/jats:italic>\n                    on kidneys of 1\u2010wk\u2010old mice. Microarray analyses revealed that the significantly changed functional categories in\n                    <jats:italic>Aqp11<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice were similar to those in PKD animals. Histochemical studies showed expression changes of 3 genes,\n                    <jats:italic>Myc, Egfr, Egf<\/jats:italic>\n                    , which are assumed to be involved in the proliferation of cystic cells in PKD. We actually confirmed the activation of cell proliferation in the proximal tubule cells with vacuolized ER. Furthermore, three genes associated with the remodeling of the extracellular matrix,\n                    <jats:italic>Mmp12, Timpl, Tgfbl<\/jats:italic>\n                    , were up\u2010regulated in the fibroblasts. We also demonstrated the activation of apoptosis\n                    <jats:italic>via<\/jats:italic>\n                    the ER\u2010stress pathway in the proximal tubule cells with vacuolized ER. These results provide new insights into the physiological roles of AQP11.\u2014Okada, S., Misaka, T., Tanaka, Y., Matsumoto, I., Ishibashi, K., Sasaki, S., Abe, K. Aquaporin\u201011 knockout mice and polycystic kidney disease animals share a common mechanism of cyst formation.\n                    <jats:italic>FASEB J.<\/jats:italic>\n                    22, 3672\u20133684 (2008)\n                  <\/jats:p>","DOI":"10.1096\/fj.08-111872","type":"journal-article","created":{"date-parts":[[2008,7,7]],"date-time":"2008-07-07T20:44:58Z","timestamp":1215463498000},"page":"3672-3684","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Aquaporin\u201011 knockout mice and polycystic kidney disease animals share a common mechanism of cyst formation"],"prefix":"10.1096","volume":"22","author":[{"given":"Shinji","family":"Okada","sequence":"first","affiliation":[{"name":"Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences The University of Tokyo Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takumi","family":"Misaka","sequence":"additional","affiliation":[{"name":"Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences The University of Tokyo Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuko","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Medical Physiology Meiji Pharmaceutical University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ichiro","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences The University of Tokyo Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Ishibashi","sequence":"additional","affiliation":[{"name":"Department of Medical Physiology Meiji Pharmaceutical University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sei","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Department of Nephrology Tokyo Medical and Dental University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiko","family":"Abe","sequence":"additional","affiliation":[{"name":"Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences The University of Tokyo Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,7,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1513\/pats.200510-109JH"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2006.02.024"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2091-7-14"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.25.17.7770-7779.2005"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2005.03.046"},{"key":"e_1_2_6_7_1","first-page":"20","article-title":"Aquaporin superfamily with unusual npa boxes: S\u2010aquaporins (superfamily, sip\u2010like and subcellular\u2010aquaporins)","volume":"52","author":"Ishibashi K.","year":"2006","journal-title":"Cell. 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