{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:18:50Z","timestamp":1790702330871,"version":"4.1.0"},"reference-count":62,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T00:00:00Z","timestamp":1217548800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["CA 089362"],"award-info":[{"award-number":["CA 089362"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK 069348"],"award-info":[{"award-number":["DK 069348"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2008,11]]},"abstract":"<jats:p>\n                    A significant unresolved question is how vitamin A deprivation causes, and why retinoic acid fails to reverse, immunodeficiency. When depleted of vitamin A, T cells undergo programmed cell death (PCD), which is enhanced by the natural competitor of retinol, anhydroretinol. PCD does not happen by apoptosis, despite the occurrence of shared early events, including mitochondrial membrane depolarization, permeability transition pore opening, and cytochrome\n                    <jats:italic>c<\/jats:italic>\n                    release. It also lacks caspase\u20103 activation, chromatin condensation, and endonuclease\u2010mediated DNA degradation, hallmarks of apoptosis. PCD following vitamin Adeprivation exhibits increased production of reactive oxygen species (ROS), drastic reductions in ATP and NAD\n                    <jats:sup>+<\/jats:sup>\n                    levels, and activation of poly\u2010(ADP\u2010ribose) polymerase (PARP) \u20101. These latter steps are causative because neutralizing ROS, imposing hypoxic conditions, or inhibiting PARP\u20101 by genetic or pharmacologic approaches prevents energy depletion and PCD. The data highlight a novel regulatory role of vitamin A in mitochondrial energy homeostasis.\u2014 Chiu, H.\u2010J., Fischman, D. A., Hammerling, U. Vitamin A depletion causes oxidative stress, mitochondrial dysfunction, and PARP\u20101\u2010dependent energy deprivation.\n                    <jats:italic>FASEB J.<\/jats:italic>\n                    22, 3878\u20133887 (2008)\n                  <\/jats:p>","DOI":"10.1096\/fj.08-112375","type":"journal-article","created":{"date-parts":[[2008,8,1]],"date-time":"2008-08-01T21:41:50Z","timestamp":1217626910000},"page":"3878-3887","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":74,"title":["Vitamin A depletion causes oxidative stress, mitochondrial dysfunction, and PARP\u20101\u2010dependent energy deprivation"],"prefix":"10.1096","volume":"22","author":[{"given":"Haw\u2010Jyh","family":"Chiu","sequence":"first","affiliation":[{"name":"Memorial Sloan\u2010Kettering Cancer Center Immunology Program New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald A.","family":"Fischman","sequence":"additional","affiliation":[{"name":"Department of Cell and Developmental Biology Weill Medical College of Cornell University New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Hammerling","sequence":"additional","affiliation":[{"name":"Memorial Sloan\u2010Kettering Cancer Center Immunology Program New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,8]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.5.14.1661245"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1749937"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.32.18875"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00169a001"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.171.5.1613"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.178.2.675"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.176.1.109"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.103.048900"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.184.2.549"},{"issue":"15","key":"e_1_2_6_11_1","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.1242\/jcs.112.15.2521","article-title":"F\u2010actin as a functional target for retro\u2010retinoids: a potential role in anhydroretinol\u2010triggered cell death","volume":"112","author":"Korichneva I.","year":"1999","journal-title":"J. Cell Sci."},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.192.6.835"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110750200"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M412695200"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.00-0329fje"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M205634200"},{"key":"e_1_2_6_17_1","first-page":"3985","article-title":"Anhydroretinol induces oxidative stress and cell death","volume":"59","author":"Chen Y.","year":"1999","journal-title":"Cancer Res."},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.281.5381.1312"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0921-8777(00)00016-1"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2571(99)00024-2"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-472X(03)00083-3"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2007.00567.x"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1097-1089"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2005.02.035"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.24.13978"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-6147(98)01193-6"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M414526200"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2006.08.009"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0027-5107(01)00111-7"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.20289"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(99)77214-0"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0005-2728(98)00112-1"},{"key":"e_1_2_6_33_1","first-page":"1835","article-title":"Intracellular ATP levels determine cell death fate by apoptosis or necrosis","volume":"57","author":"Eguchi Y.","year":"1997","journal-title":"Cancer Res."},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.185.8.1481"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80085-9"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-4889(96)00004-3"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2003.00335.x"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/35008121"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00761.2007"},{"key":"e_1_2_6_40_1","first-page":"569","article-title":"Wound healing: the effect of macrophage and tumour derived angiogenesis factors on skin graft vascularization","volume":"68","author":"Arnold F.","year":"1987","journal-title":"Br. J. Exp. Pathol."},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01715494"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0030174"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V85.2.359.359"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0145-2126(02)00162-5"},{"key":"e_1_2_6_45_1","first-page":"1945","article-title":"Intracellular glutathione levels determine cell sensitivity to apoptosis induced by the antineoplasic agent N\u2010(4\u2010hydroxyphenyl) retinamide","volume":"25","author":"Morales M. C.","year":"2005","journal-title":"Anticancer Res."},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6600356"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1203024"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.178.6.1995"},{"key":"e_1_2_6_49_1","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1093\/jnci\/djh268","article-title":"Fenretinide activates a distinct apoptotic pathway","volume":"96","author":"Dmitrovsky E.","year":"2004","journal-title":"J. Natl. Cancer Inst."},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-006-9289-3"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0004(00)01780-1"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1006\/nbdi.2000.0324"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03401936"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(99)01335-9"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2003.tb07471.x"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2003.08.008"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200609074"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.20.11715"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2006.033506"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-34817-9_15"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2006.02.002"},{"key":"e_1_2_6_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2006.01.012"},{"key":"e_1_2_6_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.01.047"}],"container-title":["The FASEB Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.08-112375","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1096\/fj.08-112375","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.08-112375","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T21:52:32Z","timestamp":1761688352000},"score":1,"resource":{"primary":{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/10.1096\/fj.08-112375"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,8]]},"references-count":62,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2008,11]]}},"alternative-id":["10.1096\/fj.08-112375"],"URL":"https:\/\/doi.org\/10.1096\/fj.08-112375","archive":["Portico"],"relation":{},"ISSN":["0892-6638","1530-6860"],"issn-type":[{"value":"0892-6638","type":"print"},{"value":"1530-6860","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,8]]},"assertion":[{"value":"2008-04-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2008-07-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2008-08-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}