{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T06:50:56Z","timestamp":1779346256720,"version":"3.51.4"},"reference-count":39,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2008,9,8]],"date-time":"2008-09-08T00:00:00Z","timestamp":1220832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MOP\u201068930"],"award-info":[{"award-number":["MOP\u201068930"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2008,12]]},"abstract":"<jats:p>\n                    Cysteinyl leukotrienes (CysLTs) are potent mediators of inflammation synthesized by the concerted actions of 5\u2010lipoxygenase (5\u2010LO), 5\u2010LO\u2010activating protein (FLAP), leukotriene C\n                    <jats:sub>4<\/jats:sub>\n                    synthase, and additional downstream enzymes, starting with arachidonic acid substrate. CysLTs produced by macrophages, eosinophils, mast cells, and other inflammatory cells activate 3 different high\u2010affinity CysLT receptors: CysLT\n                    <jats:sub>1<\/jats:sub>\n                    R, CysLT\n                    <jats:sub>2<\/jats:sub>\n                    R, and GPR 17. We sought to investigate vascular sites of CysLT\n                    <jats:sub>2<\/jats:sub>\n                    R expression and the role and mechanism of this receptor in mediating vascular permeability events. Vascular expression of CysLT\n                    <jats:sub>2<\/jats:sub>\n                    R was investigated by reporter gene expression in a novel CysLT\n                    <jats:sub>2<\/jats:sub>\n                    R deficient\u2010LacZ mouse model. CysLT\n                    <jats:sub>2<\/jats:sub>\n                    R was expressed in small, but not large, vessels in mouse brain, bladder, skin, and cremaster muscle. Intravital, in addition to confocal and electron, microscopy investigations using FIT C\u2010labeled albumin in cremaster postcapillary venule preparations indicated rapid CysLT\u2010mediated permeability, which was blocked by application of BAY\u2010u9773, a dual CysLT\n                    <jats:sub>1<\/jats:sub>\n                    R\/CysLT\n                    <jats:sub>2<\/jats:sub>\n                    R antagonist or by CysLT\n                    <jats:sub>2<\/jats:sub>\n                    R deficiency. Endothelial human CysLT\n                    <jats:sub>2<\/jats:sub>\n                    R overexpression in mice exacerbated vascular leakage even in the absence of exogenous ligand. The enhanced vascular permeability mediated by CysLT\n                    <jats:sub>2<\/jats:sub>\n                    R takes place\n                    <jats:italic>via<\/jats:italic>\n                    a transendothelial vesicle transport mechanism as opposed to a paracellular route and is controlled\n                    <jats:italic>via<\/jats:italic>\n                    Ca\n                    <jats:sup>2+<\/jats:sup>\n                    signaling. Our results reveal that CysLT\n                    <jats:sub>2<\/jats:sub>\n                    R can mediate inflammatory reactions in a vascular bed\u2010specific manner by altering transendothelial vesicle transport\u2010based vascular permeability.\u2014 Moos, M. P. W., Mewburn, J. D., Kan, F. W. K., Ishii, S., Abe, M., Sakimura, K., Noguchi, K., Shimizu, T., Funk, C. D. Cysteinyl leukotriene 2 receptor\u2010mediated vascular permeability\n                    <jats:italic>via<\/jats:italic>\n                    transendothelial vesicle transport.\n                    <jats:italic>FASEB J.<\/jats:italic>\n                    22, 4352\u20134362 (2008)\n                  <\/jats:p>","DOI":"10.1096\/fj.08-113274","type":"journal-article","created":{"date-parts":[[2008,9,8]],"date-time":"2008-09-08T20:44:20Z","timestamp":1220906660000},"page":"4352-4362","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Cysteinyl leukotriene 2 receptor\u2010mediated vascular permeability\n                    <i>via<\/i>\n                    transendothelial vesicle transport"],"prefix":"10.1096","volume":"22","author":[{"given":"Michael P. W.","family":"Moos","sequence":"first","affiliation":[{"name":"Department of Physiology Queen's University Kingston Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey D.","family":"Mewburn","sequence":"additional","affiliation":[{"name":"Division of Cancer Biology and Genetics Cancer Research Institute Queen's University Kingston Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederick W. K.","family":"Kan","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology Queen's University Kingston Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Ishii","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Faculty of Medicine University of Tokyo Tokyo Japan"},{"name":"Precursory Research for Embryonic Science and Technology (PRESTO) Japan Science and Technology Agency Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manabu","family":"Abe","sequence":"additional","affiliation":[{"name":"Department of Cellular Neurobiology Brain Research Institute, Niigata University Niigata City Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Sakimura","sequence":"additional","affiliation":[{"name":"Department of Cellular Neurobiology Brain Research Institute, Niigata University Niigata City Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyoko","family":"Noguchi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Faculty of Medicine University of Tokyo Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takao","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Faculty of Medicine University of Tokyo Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colin D.","family":"Funk","sequence":"additional","affiliation":[{"name":"Department of Physiology Queen's University Kingston Ontario Canada"},{"name":"Department of Biochemistry Queen's University Kingston Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,9,8]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"RA225","article-title":"The inflammatory response: an efficient way of life","volume":"12","author":"Aller M. 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