{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:45:55Z","timestamp":1791409555096,"version":"4.3.3"},"reference-count":58,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2009,5,11]],"date-time":"2009-05-11T00:00:00Z","timestamp":1242000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100005492","name":"Stanford University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001663","name":"Volkswagen Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2009,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    To understand the link between peripheral immune activation and neuronal precursor biology, we investigated the effect of T\u2010cell activation on adult hippocampal neurogenesis in female C57Bl\/6 mice. A peripheral adaptive immune response triggered by adjuvant\u2010induced rheumatoid arthritis (2 \u03bcg \/ \u03bcl methylated BSA) or staphylococcus enterotoxin B (EC\n                    <jats:sub>50<\/jats:sub>\n                    of 0.25 \u03bcg\/ml per 20 g body weight) was associated with a transient increase in hippocampal precursor cell proliferation and neurogenesis as assessed by immunohistochemistry and confocal microscopy. Both treatments were paralleled by an increase in corticosterone levels in the hippocampus 1\u2010 to 2\u2010fold over the physiological amount measured by quantitative radioimmunoassay. In contrast, intraperitoneal administration of the innate immune response activator lipopolysaccaride (EC\n                    <jats:sub>50<\/jats:sub>\n                    of 0.5 \u03bcg\/ml per 20 g body weight) led to a chronic 5\u2010fold increase of hippocampal glucocorticoid levels and a decrease of adult neurogenesis.\n                    <jats:italic>In vitro<\/jats:italic>\n                    exposure of murine neuronal progenitor cells to corticosterone triggered either cell death at high (1.5 nM) or proliferation at low (0.25 nM) concentrations. This effect could be blocked using a viral vector system expressing a transdomain of the glucocorticoid receptor. We suggest an evolutionary relevant communication route for the brain to respond to environmental stressors like inflammation mediated by glucocorticoid levels in the hippocampus.\u2014Wolf, S. A., Steiner, B., Wengner, A., Lipp, M., Kammertoens, T., Kempermann, G. Adaptive peripheral immune response increases proliferation of neural precursor cells in the adult hippocampus.\n                    <jats:italic>FASEBJ.<\/jats:italic>\n                    23, 3121\u20133128 (2009).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.08-113944","type":"journal-article","created":{"date-parts":[[2009,5,11]],"date-time":"2009-05-11T21:09:21Z","timestamp":1242076161000},"page":"3121-3128","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":63,"title":["Adaptive peripheral immune response increases proliferation of neural precursor cells in the adult hippocampus"],"prefix":"10.1096","volume":"23","author":[{"given":"Susanne A.","family":"Wolf","sequence":"first","affiliation":[{"name":"Neuronal Stem Cells Research Group Max Delbr\u00fcck Centre for Molecular Medicine Berlin-Buch Germany"},{"name":"Institute of Biological Sciences Institute of Neurosurgery Stanford University Stanford CA USA"},{"name":"Institute of Anatomy Department of Cell and Neurobiology University Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Steiner","sequence":"additional","affiliation":[{"name":"Neuronal Stem Cells Research Group Max Delbr\u00fcck Centre for Molecular Medicine Berlin-Buch Germany"},{"name":"Volkswagenstiftung Research Group Department of Experimental Neurology Berlin Germany"},{"name":"Department of Neurology Charit\u00e9 University Medicine Berlin Campus Virchow Klinikum Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antje","family":"Wengner","sequence":"additional","affiliation":[{"name":"Molecular Tumor Genetics Research Group Max Delbr\u00fcck Centre for Molecular Medicine Berlin-Buch Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Lipp","sequence":"additional","affiliation":[{"name":"Molecular Tumor Genetics Research Group Max Delbr\u00fcck Centre for Molecular Medicine Berlin-Buch Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Kammertoens","sequence":"additional","affiliation":[{"name":"Molecular Immunology and Genetherapy Research Group Max Delbr\u00fcck Centre for Molecular Medicine Berlin-Buch Germany"},{"name":"Institutes of Immunology Charit\u00e9 Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerd","family":"Kempermann","sequence":"additional","affiliation":[{"name":"Neuronal Stem Cells Research Group Max Delbr\u00fcck Centre for Molecular Medicine Berlin-Buch Germany"},{"name":"Volkswagenstiftung Research Group Department of Experimental Neurology Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,5,11]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(08)60500-2"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2704997"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.57.10.925"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.21.1.55"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-0618(97)00031-8"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901240303"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-03-00635.2002"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2303"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/3305"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1316.075"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.20155"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2003-0097"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2008.06.085"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2297"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1088417"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2234031100"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1629"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/YCO.0b013e3282fad375"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.20167"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/6368"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.10945"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/386493a0"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1970"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2298"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0000388"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1296"},{"key":"e_1_2_5_28_1","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1038\/scientificamerican0697-116","article-title":"Gene therapy for the nervous system","volume":"276","author":"Ho D. Y.","year":"1997","journal-title":"Sci. Am."},{"key":"e_1_2_5_29_1","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3109\/03009748109102875","article-title":"Antigen-induced arthritis: inflammation and antigen handling","volume":"40","author":"Van Beusekom H. J.","year":"1981","journal-title":"Scand. J. Rheumatol. Suppl."},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780150402"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1699-0463.1994.tb04839.x"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.130.4.1775"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2826.2001.00715.x"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01416.2005"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2911756"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19960520)369:1<56::AID-CNE4>3.0.CO;2-J"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1994.tb39269.x"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(94)90224-0"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.20074"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(03)00090-3"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.490210113"},{"key":"e_1_2_5_42_1","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1007\/s11064-007-9520-9","article-title":"the stalk to down under about brain glucocorticoid receptors, stress and development","volume":"33","author":"Kloet E. R.","year":"2008","journal-title":"Neurochem. Res."},{"key":"e_1_2_5_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/0960-0760(93)90073-6"},{"key":"e_1_2_5_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.20467"},{"key":"e_1_2_5_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/embo-reports\/kvd088"},{"key":"e_1_2_5_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1474-9728.2004.00130.x"},{"key":"e_1_2_5_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2156"},{"key":"e_1_2_5_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2005.10.006"},{"key":"e_1_2_5_49_1","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/j.neuroscience.2008.06.052","article-title":"Brain inflammation and adult neurogenesis: the dual role of microglia","volume":"158","author":"Ekdahl C. T.","year":"2008","journal-title":"Neuroscience"},{"key":"e_1_2_5_50_1","doi-asserted-by":"publisher","DOI":"10.1006\/jaut.2001.0534"},{"key":"e_1_2_5_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2006.01.458"},{"key":"e_1_2_5_52_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612053381602"},{"key":"e_1_2_5_53_1","doi-asserted-by":"publisher","DOI":"10.1159\/000127161"},{"key":"e_1_2_5_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2007.08.006"},{"key":"e_1_2_5_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1720"},{"key":"e_1_2_5_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1053"},{"key":"e_1_2_5_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature02069"},{"key":"e_1_2_5_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2826.2004.01173.x"},{"key":"e_1_2_5_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10262"}],"container-title":["The FASEB Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.08-113944","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1096\/fj.08-113944","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.08-113944","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T19:42:28Z","timestamp":1761680548000},"score":1,"resource":{"primary":{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/10.1096\/fj.08-113944"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,5,11]]},"references-count":58,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2009,9]]}},"alternative-id":["10.1096\/fj.08-113944"],"URL":"https:\/\/doi.org\/10.1096\/fj.08-113944","archive":["Portico"],"relation":{},"ISSN":["0892-6638","1530-6860"],"issn-type":[{"value":"0892-6638","type":"print"},{"value":"1530-6860","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,5,11]]},"assertion":[{"value":"2008-09-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2009-04-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2009-05-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}