{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:42:59Z","timestamp":1790775779742,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,10,8]],"date-time":"2008-10-08T00:00:00Z","timestamp":1223424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/us\/"}],"funder":[{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2009,2]]},"abstract":"<jats:p>\n                    Egression of inflammatory cells from the lung interstitium into the airway lumen is critical for the resolution of inflammation, but the underlying mechanisms of this egression are unclear. Here' we use an\n                    <jats:italic>in vitro<\/jats:italic>\n                    system, in which human T cells migrate across a bronchial epithelial monolayer, to investigate the molecules involved. We show that although inhibition of T\u2010cell LFA\u20101 blocks egression by 75 \u00b1 5.6% (P&lt;0.0001), inhibition of the LFA\u20101\u2010ligand ICAM\u20101 on the epithelium only inhibits by 52.7 \u00b1 0.06% (P=0.0001). We, therefore, looked for other epithelial ligands for LFA\u20101 and demonstrate that ICAM\u20102, but not ICAM\u20103, is expressed on the bronchial epithelium. Blocking ICAM\u20102 inhibits egression by 50.95 \u00b1 10.79% (P=0.04), and blocking both ICAM\u20101 and ICAM\u20102 inhibits egression by 69.6 \u00b1 5.2% (P&lt; 0.0001). Inhibition of LFA\u20101\/ICAM\u20101 and ICAM\u20102 interactions on the basolateral epithelium does not prevent egressing T cells from adhering, polarizing, or moving over the basal epithelium, but it does prevent their recognition of the interepithelial junctions. In conclusion, we show that egression of T cells involves three distinct sequential steps: adhesion, junctional recognition, and diapedesis; we further demonstrate that ICAM\u20102 is expressed on the bronchial epithelium and, together with ICAM\u20101, has an essential function in the clearance of T cells from the lung.\u2014Porter, J. C., Hall, A. Epithelial ICAM\u20101 and ICAM\u20102 regulate the egression of human T cells across the bronchial epithelium.\n                    <jats:italic>FASEB J.<\/jats:italic>\n                    23, 492\u2010502 (2009)\n                  <\/jats:p>","DOI":"10.1096\/fj.08-115899","type":"journal-article","created":{"date-parts":[[2008,10,8]],"date-time":"2008-10-08T21:07:03Z","timestamp":1223500023000},"page":"492-502","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Epithelial ICAM\u20101 and ICAM\u20102 regulate the egression of human T cells across the bronchial epithelium"],"prefix":"10.1096","volume":"23","author":[{"given":"Joanna C.","family":"Porter","sequence":"first","affiliation":[{"name":"Medical Research Council Laboratory of Molecular Cell Biology University College London London UK"},{"name":"Department of Respiratory Medicine University College London Hospitals National Health Service Trust, University College London Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Hall","sequence":"additional","affiliation":[{"name":"Cell Biology Program Memorial Sloan\u2010Kettering Cancer Center New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,10,8]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2254"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80002-3"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.188.1.157"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.26.021607.090312"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1238"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1240"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni773"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.03-1412fje"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.3.1866"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.19.6.3245mrev"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.187.12.1927"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.116.1.219"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.153.7.3189"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3003.1999.13f16.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03401908"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20060925"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1051"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2005.01.007"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.162.5.2964"},{"key":"e_1_2_6_21_1","doi-asserted-by":"crossref","first-page":"5755","DOI":"10.4049\/jimmunol.161.10.5755","article-title":"ICAM\u20101 signaling pathways associated with Rho activation in microvascular brain endothelial cells","volume":"161","author":"Etienne S.","year":"1998","journal-title":"J. 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