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Herein, we investigated the role of MIF in eosinophilopoiesis and tissue eosinophilia using\n                    <jats:italic>Schistosoma mansoni<\/jats:italic>\n                    infection. MIF\u2010deficient (\n                    <jats:italic>Mif<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    ) mice had similar numbers of adult worms, eggs, and granulomas compared to wildtype mice, but the size of granulomas was strikingly reduced due to smaller numbers of eosinophils. MIF did not affect the acquired response to infection, as\n                    <jats:italic>Mif<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice produced normal amounts of Th2 cytokines and IgE. Nevertheless, recombinant MIF (rMIF) behaved as a chemoattractant for eosinophils, what could partially explain the reduced eosinophilia in infected\n                    <jats:italic>Mif<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice. Moreover, the percentage of eosinophils was reduced in bone marrows of\n                    <jats:italic>Mif<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice chronically infected with\n                    <jats:italic>S. mansoni<\/jats:italic>\n                    compared to wild type.\n                    <jats:italic>Mif<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    had impaired eosinophilopoiesis in response to interleukin (IL)\u20105 and addition of rMIF to bone marrow cultures from IL\u20105 transgenic mice enhanced the generation of eosinophils. In the absence of MIF, eosinophil precursors were unable to survive the IL\u20105\u2010supplemented cell culture, and were ingested by macrophages. Treatment with pancaspase inhibitor z\u2010VAD or rMIF promoted the survival of eosinophil progenitors. Together, these results indicate that MIF participates in IL\u20105\u2010driven maturation of eosinophils and in tissue eosinophilia associated with\n                    <jats:italic>S. mansoni<\/jats:italic>\n                    infection.\u2014Magalhaes, E. S., Paiva, C. N., Souza, H. S. P., Pyrrho, A. S., Mourao\u2010Sa, D., Figueiredo, R. T., Vieira\u2010de\u2010Abreu, A., Dutra, H. S., Silveira, M. S., Gaspar\u2010Elsas, M. I. C., Xavier\u2010Elsas, P., Bozza, P. T., Bozza, M. T. Macrophage migration inhibitory factor is critical to interleukin\u20105\u2010driven eosinophilopoiesis and tissue eosinophilia triggered by Schistosoma mansoni infection.\n                    <jats:italic>FASEB J<\/jats:italic>\n                    . 23, 1262\u20131271 (2009)\n                  <\/jats:p>","DOI":"10.1096\/fj.08-124248","type":"journal-article","created":{"date-parts":[[2008,12,16]],"date-time":"2008-12-16T22:59:28Z","timestamp":1229468368000},"page":"1262-1271","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Macrophage migration inhibitory factor is critical to interleukin\u20105\u2010driven eosinophilopoiesis and tissue eosinophilia triggered by\n                    <i>Schistosoma mansoni<\/i>\n                    infection"],"prefix":"10.1096","volume":"23","author":[{"given":"Elizabeth S.","family":"Magalhaes","sequence":"first","affiliation":[{"name":"Departamento de Imunologia Instituto de Microbiologia Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia N.","family":"Paiva","sequence":"additional","affiliation":[{"name":"Departamento de Imunologia Instituto de Microbiologia Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heitor S. P.","family":"Souza","sequence":"additional","affiliation":[{"name":"Departamento de Cl\u00ednica Medica Faculdade de Medicina Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre S.","family":"Pyrrho","sequence":"additional","affiliation":[{"name":"Departamento de Farmacia Instituto de Biologia Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Mourao-S\u00e1","sequence":"additional","affiliation":[{"name":"Departamento de Imunologia Instituto de Microbiologia Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo T.","family":"Figueiredo","sequence":"additional","affiliation":[{"name":"Departamento de Imunologia Instituto de Microbiologia Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Vieira-de-Abreu","sequence":"additional","affiliation":[{"name":"Laboratorio de Imunofarmacologia Instituto Oswaldo Cruz Instituto Fernandes Figueira Fiocruz Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helio S.","family":"Dutra","sequence":"additional","affiliation":[{"name":"Departamento de Histologia e Embriologia Instituto de Ci\u00eancias Biomedicas Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana S.","family":"Silveira","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Neurog\u00eanese Instituto de Biof\u00edsca Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Ignez C.","family":"Gaspar-Elsas","sequence":"additional","affiliation":[{"name":"Departamento de Pediatria Instituto Fernandes Figueira Fiocruz Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Xavier-Elsas","sequence":"additional","affiliation":[{"name":"Departamento de Imunologia Instituto de Microbiologia Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patr\u00edcia T.","family":"Bozza","sequence":"additional","affiliation":[{"name":"Laboratorio de Imunofarmacologia Instituto Oswaldo Cruz Instituto Fernandes Figueira Fiocruz Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo T.","family":"Bozza","sequence":"additional","affiliation":[{"name":"Departamento de Imunologia Instituto de Microbiologia Universidade Federal do Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,12,16]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2007-0065"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.190.10.1375"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.03-0110com"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.012511599"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.189.2.341"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.2.906-911.2001"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.shk.0000140305.01641.c8"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.3.1247-1254.2003"},{"key":"e_1_2_5_10_1","first-page":"389","article-title":"Macrophage migration inhibitory factor and its role in autoimmune diseases","volume":"52","author":"Denkinger C. 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