{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T04:11:21Z","timestamp":1791087081030,"version":"4.1.0"},"reference-count":49,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2009,4,13]],"date-time":"2009-04-13T00:00:00Z","timestamp":1239580800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["PPG HL\u201348788"],"award-info":[{"award-number":["PPG HL\u201348788"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2009,8]]},"abstract":"<jats:p>\n                    Identifying the molecular mechanisms activated in compensatory hypertrophy and absent during decompensation will provide molecular targets for prevention of heart failure. We have previously shown enhanced ubiquitination (Ub) during the early growth period of pressure overload (PO) hypertrophy near intercalated discs of cardiomyocytes, where integrins are important for mechanotransduction. In this study, we tested the role of integrins upstream of Ub, whether enhanced Ub contributes to survival signaling in early PO, and if loss of this mechanism could lead to decreased ventricular function. The study used a \u03b2\n                    <jats:sub>3<\/jats:sub>\n                    integrin (\n                    <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    ) mouse and a wild\u2010type mouse as a control for\n                    <jats:italic>in vivo<\/jats:italic>\n                    PO by transverse aortic constriction (TAC) and for cultured cardiomyocytes\n                    <jats:italic>in vitro<\/jats:italic>\n                    , stimulated with the integrin\u2010activating peptide RGD. We demonstrate \u03b2\n                    <jats:sub>3<\/jats:sub>\n                    integrin mediates transient Ub of targeted proteins during PO hypertrophy, which is necessary for cardiomyocyte survival and to maintain ventricular function. Prosurvival signaling proceeds by initiation of NF\u2010KB transcription of the E3 ligase, cIAP1. In PO \u03b1\n                    <jats:sub>3<\/jats:sub>\n                    <jats:sup>\u2013\/\u2013<\/jats:sup>\n                    mice, absence of this mechanism correlates with increased TUNEL staining and decreased ventricular mass and function by 4 wk. This is the first study to show that a \u03b2\n                    <jats:sub>3<\/jats:sub>\n                    integrin\/Ub\/NF\u2010KB pathway contributes to compensatory hypertrophic growth.\u2014 Johnston, R. K., Balasubramanian, S., Kasiganesan, H., Baicu, C. F., Zile, M. R., Kuppuswamy, D. \u03b23Integrin\u2010mediated ubiquitination activates survival signaling during myocardial hypertrophy. FASEBJ. 23, 2759\u20132771 (2009)\n                  <\/jats:p>","DOI":"10.1096\/fj.08-127480","type":"journal-article","created":{"date-parts":[[2009,4,13]],"date-time":"2009-04-13T20:14:08Z","timestamp":1239653648000},"page":"2759-2771","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["\u03b2\n                    <sub>3<\/sub>\n                    Integrin\u2010mediated ubiquitination activates survival signaling during myocardial hypertrophy"],"prefix":"10.1096","volume":"23","author":[{"given":"Rebecca K.","family":"Johnston","sequence":"first","affiliation":[{"name":"Cardiology Division of the Department of Medicine Gazes Cardiac Research Institute Medical University of South Carolina Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sundaravadivel","family":"Balasubramanian","sequence":"additional","affiliation":[{"name":"Cardiology Division of the Department of Medicine Gazes Cardiac Research Institute Medical University of South Carolina Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harinath","family":"Kasiganesan","sequence":"additional","affiliation":[{"name":"Cardiology Division of the Department of Medicine Gazes Cardiac Research Institute Medical University of South Carolina Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catalin F.","family":"Baicu","sequence":"additional","affiliation":[{"name":"Cardiology Division of the Department of Medicine Gazes Cardiac Research Institute Medical University of South Carolina Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Zile","sequence":"additional","affiliation":[{"name":"Cardiology Division of the Department of Medicine Gazes Cardiac Research Institute Medical University of South Carolina Charleston South Carolina USA"},{"name":"Ralph H. Johnson Department of Veterans Affairs Medical Center Gazes Cardiac Research Institute Medical University of South Carolina Charleston South Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhandapani","family":"Kuppuswamy","sequence":"additional","affiliation":[{"name":"Cardiology Division of the Department of Medicine Gazes Cardiac Research Institute Medical University of South Carolina Charleston South Carolina USA"},{"name":"Ralph H. 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