{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T23:50:06Z","timestamp":1790898606307,"version":"4.1.0"},"reference-count":60,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2009,4,3]],"date-time":"2009-04-03T00:00:00Z","timestamp":1238716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2009,8]]},"abstract":"<jats:p>\n                    Schistosomes are intravascular, parasitic helminths that cause a chronic, often debilitating disease afflicting over 200 million people in over 70 countries. Here we describe novel imaging methods that, for the first time, permit visualization of live schistosomes within their living hosts. The technology centers on fluorescent agent uptake and activation in the parasite's gut, and subsequent detection and signal quantitation using fluorescence molecular tomography (FMT). There is a strong positive correlation between the signal detected and parasite number.\n                    <jats:italic>Schistosoma mansoni<\/jats:italic>\n                    parasites of both sexes recovered from infected experimental animals exhibit vivid fluorescence throughout their intestines. Likewise, the remaining important human schistosome parasites,\n                    <jats:italic>S. japonicum<\/jats:italic>\n                    and\n                    <jats:italic>S. hematobium<\/jats:italic>\n                    , also exhibit gut fluorescence when recovered from infected animals. Imaging has been used to efficiently document the decline in parasite numbers in infected mice treated with the antischistosome drug praziquantel. This technology will provide a unique opportunity both to help rapidly identify much\u2010 needed, novel antischistosome therapies and to gain direct visual insight into the intravascular lives of the major schistosome parasites of humans.\u2014 Krautz\u2010Peter\u2010son, G.,Ndegwa, D., Vasquez, K., Korideck, H., Zhang, J., Peterson, J. D., Skelly, P. J. Imaging schistosomes\n                    <jats:italic>in vivo<\/jats:italic>\n                    . FASEBJ. 23, 2673\u20132680 (2009)\n                  <\/jats:p>","DOI":"10.1096\/fj.08-127738","type":"journal-article","created":{"date-parts":[[2009,4,3]],"date-time":"2009-04-03T21:34:06Z","timestamp":1238794446000},"page":"2673-2680","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Imaging schistosomes\n                    <i>in vivo<\/i>"],"prefix":"10.1096","volume":"23","author":[{"given":"Greice","family":"Krautz\u2010Peterson","sequence":"first","affiliation":[{"name":"Molecular Helminthology Laboratory Division of Infectious Diseases Department of Biomedical Sciences Tufts University Cummings School of Veterinary Medicine North Grafton Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Ndegwa","sequence":"additional","affiliation":[{"name":"Molecular Helminthology Laboratory Division of Infectious Diseases Department of Biomedical Sciences Tufts University Cummings School of Veterinary Medicine North Grafton Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristine","family":"Vasquez","sequence":"additional","affiliation":[{"name":"VisEn Medical Incorporated Bedford Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Houari","family":"Korideck","sequence":"additional","affiliation":[{"name":"VisEn Medical Incorporated Bedford Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Zhang","sequence":"additional","affiliation":[{"name":"VisEn Medical Incorporated Bedford Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey D.","family":"Peterson","sequence":"additional","affiliation":[{"name":"VisEn Medical Incorporated Bedford Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick J.","family":"Skelly","sequence":"additional","affiliation":[{"name":"Molecular Helminthology Laboratory Division of Infectious Diseases Department of Biomedical Sciences Tufts University Cummings School of Veterinary Medicine North Grafton Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,4,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/1742395307084407"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.1982.tb00377.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(74)90002-2"},{"key":"e_1_2_7_5_1","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1080\/00034983.1959.11685939","article-title":"Chronological analysis, pattern and rate of migration of cercariae of Schistosoma mansoni in body, ear and tail skin of mice","volume":"53","author":"Stirewalt M. 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