{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T15:00:26Z","timestamp":1791126026775,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2009,10,5]],"date-time":"2009-10-05T00:00:00Z","timestamp":1254700800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2009,10,5]],"date-time":"2009-10-05T00:00:00Z","timestamp":1254700800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01\u2010DK54380"],"award-info":[{"award-number":["R01\u2010DK54380"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2010,2]]},"abstract":"<jats:p>\n                    Glucose\u20106\u2010phosphate dehydrogenase (G6PD) is the rate\u2010limiting enzyme of the pentose phosphate pathway and the principal source of NADPH, a major cellular reductant, and is central to cell survival. Our previous work showed that diabetes and increased aldosterone are acquired forms of G6PD deficiency, leading to decreased G6PD activity and NADPH levels and damage to kidney tissue and endothelial cells. In this study, G6PD\u2010deficient mice were studied to test the hypothesis that decreased G6PD activity\n                    <jats:italic>per se<\/jats:italic>\n                    can cause changes similar to those seen in the acquired conditions of G6PD deficiency. Results show that as compared with control mice, G6PD\u2010deficient mice had increased oxidative stress, as manifested by decreased NADPH levels and decreased GSH levels, and increased markers of lipid peroxidation. G6PD\u2010deficient mice had increased protein kinase C activity, increased nuclear factor\u2010\u03ba\u0392 activity, and increased urinary albumin levels, all of which is similar to changes seen in diabetic mice. Changes persisted as the mice aged, as old G6PD\u2010deficient mice (17\u201320 mo) had higher urine albumin levels and also had evidence for increased apoptosis in the renal cortex. These results show that decreased G6PD activity\n                    <jats:italic>per se<\/jats:italic>\n                    is sufficient to cause changes similar to those seen in diabetic mice.\u2014Xu, Y., Zhang, Z., Hu, J., Stillman, I. E., Leopold, J. A., Handy, D. E., Loscalzo, J., Stanton, R. C. Glucose\u20106\u2010phosphate dehydrogenase\u2010deficient mice have increased renal oxidative stress and increased albuminuria.\n                    <jats:italic>FASEB J<\/jats:italic>\n                    . 24, 609\u2013616 (2010).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.09-135731","type":"journal-article","created":{"date-parts":[[2009,10,5]],"date-time":"2009-10-05T21:21:18Z","timestamp":1254777678000},"page":"609-616","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":79,"title":["Glucose\u20106\u2010phosphate dehydrogenase\u2010deficient mice have increased renal oxidative stress and increased albuminuria"],"prefix":"10.1096","volume":"24","author":[{"given":"Yizhen","family":"Xu","sequence":"first","affiliation":[{"name":"Research Division Joslin Diabetes Center Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoyun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Research Division Joslin Diabetes Center Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji","family":"Hu","sequence":"additional","affiliation":[{"name":"Research Division Joslin Diabetes Center Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaac E.","family":"Stillman","sequence":"additional","affiliation":[{"name":"Department of Pathology Beth Israel Deaconess Medical Center Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane A.","family":"Leopold","sequence":"additional","affiliation":[{"name":"Department of Medicine Brigham and Women's Hospital Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane E.","family":"Handy","sequence":"additional","affiliation":[{"name":"Department of Medicine Brigham and Women's Hospital Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Loscalzo","sequence":"additional","affiliation":[{"name":"Department of Medicine Brigham and Women's Hospital Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert C.","family":"Stanton","sequence":"additional","affiliation":[{"name":"Research Division Joslin Diabetes Center Harvard Medical School Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,10,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2006.08.018"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.00-0893fje"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000056744.26901.BA"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1042\/bst0301091"},{"key":"e_1_2_6_6_1","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1055\/s-0028-1086023","article-title":"NAD(P)H oxidase and endothelial dysfunction","volume":"41","author":"Muller G.","year":"2009","journal-title":"Horm. 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