{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:41:19Z","timestamp":1791409279909,"version":"4.3.3"},"reference-count":46,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2009,7,7]],"date-time":"2009-07-07T00:00:00Z","timestamp":1246924800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["WT077714"],"award-info":[{"award-number":["WT077714"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2009,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Sunburn is a commonly occurring acute inflammatory process, with dermal vasodilatation and leukocyte infiltration as central features. Ultraviolet (UV) B\u2010induced hydrolysis of membrane phospholipids releases polyunsaturated fatty acids, and their subsequent metabolism by cyclooxygenases (COXs) and lipoxygenases (LOXs) may produce potent eicosanoid mediators modulating different stages of the inflammation. Our objective was to identify candidate eicosanoids formed during the sunburn reaction in relation to its clinical and histological course. We exposed skin of healthy humans (\n                    <jats:italic>n<\/jats:italic>\n                    =32) to UVB and, for 72 h, examined expression of proinflammatory and antiinflammatory eicosanoids using LC\/ESI\u2010MS\/MS, and examined immunohistochemical expression of COX\u20102, 12\u2010LOX, 15\u2010LOX, and leukocyte markers, while quantifying clinical erythema. We show that vasodilatory prostaglandins (PGs) PGE\n                    <jats:sub>2<\/jats:sub>\n                    , PGF\n                    <jats:sub>2a<\/jats:sub>\n                    , and PGE\n                    <jats:sub>3<\/jats:sub>\n                    accompany the erythema in the first 24\u201348 h, associated with increased COX\u20102 expression at 24 h. Novel, potent leukocyte chemoattractants 11\u2010, 12\u2010, and 8\u2010monohydroxy\u2010eicosatetraenoic acid (HETE) are elevated from 4 to 72 h, in association with peak dermal neutrophil influx at 24 h, and increased dermal CD3\n                    <jats:sup>+<\/jats:sup>\n                    lymphocytes and 12\u2010 and 15\u2010LOX expression from 24 to 72 h. Anti\u2010inflammatory metabolite 15\u2010HETE shows later expression, peaking at 72 h. Sunburn is characterized by overlapping sequential profiles of increases in COX products followed by LOX products that may regulate subsequent events and ultimately its resolution.\u2014Rhodes, L. E., Gledhill, K., Masoodi, M., Haylett, A. K., Brownrigg, M., Thody, A. J., Tobin, D. J., Nicolaou, A. The sunburn response in human skin is characterized by sequential eicosanoid profiles that may mediate its early and late phases.\n                    <jats:italic>FASEB J.<\/jats:italic>\n                    23, 3947\u20133956 (2009).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.09-136077","type":"journal-article","created":{"date-parts":[[2009,7,7]],"date-time":"2009-07-07T23:29:02Z","timestamp":1247009342000},"page":"3947-3956","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":111,"title":["The sunburn response in human skin is characterized by sequential eicosanoid profiles that may mediate its early and late phases"],"prefix":"10.1096","volume":"23","author":[{"given":"Lesley E.","family":"Rhodes","sequence":"first","affiliation":[{"name":"Photobiology Unit Dermatological Sciences School of Translational Medicine University of Manchester Salford Royal National Health Service Foundation Hospital Manchester Academic Health Sciences Centre Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Gledhill","sequence":"additional","affiliation":[{"name":"Centre for Skin Sciences School of Life Sciences University of Bradford Bradford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mojgan","family":"Masoodi","sequence":"additional","affiliation":[{"name":"School of Pharmacy University of Bradford Bradford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann K.","family":"Haylett","sequence":"additional","affiliation":[{"name":"Photobiology Unit Dermatological Sciences School of Translational Medicine University of Manchester Salford Royal National Health Service Foundation Hospital Manchester Academic Health Sciences Centre Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Brownrigg","sequence":"additional","affiliation":[{"name":"Photobiology Unit Dermatological Sciences School of Translational Medicine University of Manchester Salford Royal National Health Service Foundation Hospital Manchester Academic Health Sciences Centre Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony J.","family":"Thody","sequence":"additional","affiliation":[{"name":"School of Clinical and Laboratory Sciences University of Newcastle upon Tyne Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Desmond J.","family":"Tobin","sequence":"additional","affiliation":[{"name":"Centre for Skin Sciences School of Life Sciences University of Bradford Bradford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Nicolaou","sequence":"additional","affiliation":[{"name":"Centre for Skin Sciences School of Life Sciences University of Bradford Bradford UK"},{"name":"School of Pharmacy University of Bradford Bradford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,7,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022-202x.2001.01514.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1988.tb01746.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12292156"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.8.3732"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1998.00220.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1978.tb01650.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.8.2.7509761"},{"key":"e_1_2_8_9_1","first-page":"114","article-title":"Prostaglandins, leukotrienes, and hydroxy fatty acids in epidermis","volume":"11","author":"Ziboh V. 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