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Using the \u03b2\n                    <jats:italic>3KOP<\/jats:italic>\n                    and \u03b2\n                    <jats:italic>3KOM<\/jats:italic>\n                    strains of mice, we studied the role of \u03b23\u2010integrin in hemostasis, bone resorption, and subcutaneous tumor growth. Tissue\u2010specific deletion of platelet \u03b23\u2010integrins in \u03b2\n                    <jats:italic>3KOP<\/jats:italic>\n                    mice did not affect bone mass but resulted in a severe bleeding phenotype. No growth difference of tumor xenografts or in neoangiogenesis were found in \u03b2\n                    <jats:italic>3KOP<\/jats:italic>\n                    mice, in contrast to the defects observed in germline \u03b23\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice. Conditional deletion of myeloid \u03b23\u2010integrins in \u03b2\n                    <jats:italic>3KOM<\/jats:italic>\n                    mice resulted in osteopetrosis but had no effect on hemostasis or mortality. Tumor growth in \u03b2\n                    <jats:italic>3KOM<\/jats:italic>\n                    mice was increased and accompanied by decreased macrophage infiltration, without increase in blood vessel number. Platelet \u03b23\u2010integrin deficiency was sufficient to disrupt hemostasis but had no effect on bone mass or tumor growth. Myeloid\u2010specific \u03b23\u2010integrin deletion was sufficient to perturb bone mass and enhance tumor growth due to reduced macrophage infiltration in the tumors. These results suggest that \u03b23\u2010integrins have cell\u2010specific roles in complex biological processes.\u2014Morgan, E. A., Schneider, J. G., Baroni, T. E., Ulu\u00e7kan, \u00d6., Heller, E., Hurchla, M. A., Deng, H., Floyd, D., Berdy, A., Prior, J. L., Piwnica\u2010Worms, D., Teitelbaum, S. L., Ross, F. P., Weilbaecher, K. N. Dissection of platelet and myeloid cell defects by conditional targeting of the \u03b23\u2010integrin subunit.\n                    <jats:italic>FASEB J.<\/jats:italic>\n                    24,1117\u20131127 (2010).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.09-138420","type":"journal-article","created":{"date-parts":[[2009,11,20]],"date-time":"2009-11-20T20:54:22Z","timestamp":1258750462000},"page":"1117-1127","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":66,"title":["Dissection of platelet and myeloid cell defects by conditional targeting of the \u03b23\u2010integrin subunit"],"prefix":"10.1096","volume":"24","author":[{"given":"Elizabeth A.","family":"Morgan","sequence":"first","affiliation":[{"name":"Department of Medicine Washington University School of Medicine St. Louis Missouri USA"},{"name":"Division of Oncology Washington University School of Medicine St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen G.","family":"Schneider","sequence":"additional","affiliation":[{"name":"Department of Medicine Washington University School of Medicine St. Louis Missouri USA"},{"name":"Division of Oncology Washington University School of Medicine St. Louis Missouri USA"},{"name":"Department of Clinical Biochemistry and Pathobiochemistry University of W\u00fcrzburg W\u00fcrzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy E.","family":"Baroni","sequence":"additional","affiliation":[{"name":"Department of Medicine Washington University School of Medicine St. Louis Missouri USA"},{"name":"Division of Oncology Washington University School of Medicine St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozge","family":"Ulu\u00e7kan","sequence":"additional","affiliation":[{"name":"Department of Medicine Washington University School of Medicine St. Louis Missouri USA"},{"name":"Division of Oncology Washington University School of Medicine St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela","family":"Heller","sequence":"additional","affiliation":[{"name":"Department of Medicine Washington University School of Medicine St. Louis Missouri USA"},{"name":"Division of Oncology Washington University School of Medicine St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle A.","family":"Hurchla","sequence":"additional","affiliation":[{"name":"Department of Medicine Washington University School of Medicine St. Louis Missouri USA"},{"name":"Division of Oncology Washington University School of Medicine St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongju","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Medicine Washington University School of Medicine St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Desiree","family":"Floyd","sequence":"additional","affiliation":[{"name":"Department of Medicine Washington University School of Medicine St. Louis Missouri USA"},{"name":"Division of Oncology Washington University School of Medicine St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Berdy","sequence":"additional","affiliation":[{"name":"Department of Medicine Washington University School of Medicine St. Louis Missouri USA"},{"name":"Division of Oncology Washington University School of Medicine St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie L.","family":"Prior","sequence":"additional","affiliation":[{"name":"Molecular Imaging Center Mallinkrodt Institute of Radiology Washington University School of Medicine St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Piwnica-Worms","sequence":"additional","affiliation":[{"name":"Molecular Imaging Center Mallinkrodt Institute of Radiology Washington University School of Medicine St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"L. 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