{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T17:13:09Z","timestamp":1791133989391,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2010,1,26]],"date-time":"2010-01-26T00:00:00Z","timestamp":1264464000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2010,6]]},"abstract":"<jats:p>\n                    The present study evaluated the efficacy of intermittent antiviral treatment administered to HIV\u2010infected patients under stepwise reductions in weekly medication. Forty\u2010eight patients were invited to reduce their antiviral medication to 5 consecutive days per week; after control over HIV activity was ascertained, antiviral drugs were cut to 4 consecutive days per week. Of the 48, 39 then reduced medicines further to 3 d, and 12 of those eventually undertook a 2 d\/wk schedule. Clinical and immunological status and plasma HIV load were repeatedly monitored. HIV was unremittingly maintained below detection levels in all patients under either 5\u2010 or 4\u2010d\/wk treatment regimens, for a mean 56 \u00b1 40 wk\/patient (5\u2010d regimen) and 84 \u00b1 46 wk\/patient (4\u2010d regimen). Of the 39 patients under 3\u2010d regimens, 35 maintained optimal control over HIV activity for a mean 50 \u00b1 32 wk, as did 10 of the 12 under 2\u2010d regimens, for 24 \u00b1 10.5 wk. Summing up treatment \u2264 5 d\/wk, plasma HIV remained below detection levels for a cumulative 8895 wk (170 patientyr). No major HIV\u2010related clinical event was reported. and CD4\n                    <jats:sup>+<\/jats:sup>\n                    T\u2010cell counts and percentages readily increased over the last value noted under the 7\u2010d treatment course. Viral failure was documented in 6 of the 48 patients: 4 under a 3\u2010d\/wk regimen, 2 under a 2\u2010d\/wk regimen. All 6 patients had their treatment swiftly set back to a 7\u2010d\/wk regimen, resulting in rapid control over HIV replication. In summary, intermittent antiretroviral regimens optimally suppressed HIV in patients taking antiviral medicines 5 and 4 d\/wk, as well as in a substantial proportion of patients under 3\u2010 or 2\u2010d\/wk antiviral regimens, reducing both expenses and, possibly, drug toxicity. Controlled prospective clinical trials are warranted before considering short weekly cycles of antiretroviral medicines an alternative in the management of chronically HIV\u2010infected patients.\u2014Leibowitch, J., Mathez, D., de Truchis, P., Perronne, C., Melchior, J. C. Short cycles of antiretroviral drugs provide intermittent yet effective therapy: a pilot study in 48 patients with chronic HIV infection.\n                    <jats:italic>FASEB J.<\/jats:italic>\n                    24, 1649\u20131655 (2010).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.09-148676","type":"journal-article","created":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T04:57:40Z","timestamp":1275368260000},"page":"1649-1655","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Short cycles of antiretroviral drugs provide intermittent yet effective therapy: a pilot study in 48 patients with chronic HIV infection"],"prefix":"10.1096","volume":"24","author":[{"given":"Jacques","family":"Leibowitch","sequence":"first","affiliation":[{"name":"Immunology and Virology Unit Raymond Poincar\u00e9 Hospital, Assistance Publique\u2013H\u00f4pitaux de Paris Garches France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Mathez","sequence":"additional","affiliation":[{"name":"Immunology and Virology Unit Raymond Poincar\u00e9 Hospital, Assistance Publique\u2013H\u00f4pitaux de Paris Garches France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"de Truchis","sequence":"additional","affiliation":[{"name":"Clinical Infectious Disease Unit Raymond Poincar\u00e9 Hospital, Assistance Publique\u2013H\u00f4pitaux de Paris Garches France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Perronne","sequence":"additional","affiliation":[{"name":"Clinical Infectious Disease Unit Raymond Poincar\u00e9 Hospital, Assistance Publique\u2013H\u00f4pitaux de Paris Garches France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Claude","family":"Melchior","sequence":"additional","affiliation":[{"name":"Clinical Nutrition and Infectious Disease Unit, Department of Internal Medicine and Infectious Diseases Raymond Poincar\u00e9 Hospital, Assistance Publique\u2013H\u00f4pitaux de Paris Garches France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,1,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkn455"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-133-1-200007040-00004"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1086\/376989"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa062360"},{"key":"e_1_2_6_6_1","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1097\/QAD.0b013e328321b791","article-title":"Is it smart to continue to study treatment interruptions?","volume":"27","author":"Hirschel B.","year":"2009","journal-title":"AIDS"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkn097"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1258\/0956462011923507"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2007.0083"},{"key":"e_1_2_6_10_1","first-page":"7","article-title":"Anti\u2010HIV agents. Treatment interruption surprisingly does not reduce heart disease risk","volume":"21","author":"Anonymous","year":"2009","journal-title":"Treatmentupdate"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2009.36"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2008.161463"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.261568398"},{"key":"e_1_2_6_14_1","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1086\/386344","article-title":"A proof\u2010of\u2010concept study of short\u2010cycle intermittent antiretroviral therapy with a once\u2010daily regimen of didanosine, lamivudine, and efavirenz for the treatment of chronic HIV infection","volume":"189","author":"Dybul M.","year":"2004","journal-title":"J. Infect. 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