{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T23:53:09Z","timestamp":1792885989481,"version":"4.5.0"},"reference-count":42,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2010,6,16]],"date-time":"2010-06-16T00:00:00Z","timestamp":1276646400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2010,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Mast cells contribute to allergy through IgE\u2010dependent activation\n                    <jats:italic>via<\/jats:italic>\n                    the high\u2010affinity IgE receptor Fc\u03b5RI. The role of the Fc\u03b5RI\u03b2 chain (MS4A2) in mast cell function is not understood fully, although it serves to amplify Fc\u03b5RI\u2010dependent signaling. We demonstrate the expression of a novel MS4A2 truncation lacking exon 3 in human mast cells termed MS4A2\n                    <jats:sub>trunc<\/jats:sub>\n                    . MS4A2\n                    <jats:sub>trunc<\/jats:sub>\n                    gene expression was regulated negatively by the mast cell growth factor stem cell factor (SCF), and its expression was not detected in the SCF receptor gain\u2010of\u2010function human mast cell line HMC\u20101. Unlike MS4A2, MS4A2\n                    <jats:sub>trunc<\/jats:sub>\n                    did not traffic to the cytoplasmic membrane but instead was associated with the nuclear membrane. Overexpression of MS4A2\n                    <jats:sub>trunc<\/jats:sub>\n                    induced human lung mast cell death and profoundly inhibited HMC\u20101 cell proliferation by inducing G\n                    <jats:sub>2<\/jats:sub>\n                    \u2010phase cell cycle arrest and apoptosis. Thus, we have identified a novel splice variant of MS4A2 that might be important in the regulation of human mast cell proliferation and survival. This finding demonstrates that the MS4A2 gene has multiple roles, extending beyond the regulation of acute allergic responses. By understanding the mechanisms regulating its function, it might be possible to induce its expression in mast cells\n                    <jats:italic>in vivo<\/jats:italic>\n                    , which could lead to better treatments for diseases such as mastocytosis and asthma.\u2014Cruse, G., Kaur, D., Leyland, M., Bradding, P. A novel Fc\u03b5RI\u03b2\u2010chain truncation regulates human mast cell proliferation and survival.\n                    <jats:italic>FASEB J.<\/jats:italic>\n                    24, 4047\u20134057 (2010).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.10-158378","type":"journal-article","created":{"date-parts":[[2010,6,16]],"date-time":"2010-06-16T22:33:11Z","timestamp":1276727591000},"page":"4047-4057","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["A novel Fc\u03b5RI\u03b2\u2010chain truncation regulates human mast cell proliferation and survival"],"prefix":"10.1096","volume":"24","author":[{"given":"Glenn","family":"Cruse","sequence":"first","affiliation":[{"name":"Department of Infection Immunity and Inflammation Institute for Lung Health Glenfield Hospital  Leicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davinder","family":"Kaur","sequence":"additional","affiliation":[{"name":"Department of Infection Immunity and Inflammation Institute for Lung Health Glenfield Hospital  Leicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Leyland","sequence":"additional","affiliation":[{"name":"Department of Biochemistry University of Leicester  Leicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Bradding","sequence":"additional","affiliation":[{"name":"Department of Infection Immunity and Inflammation Institute for Lung Health Glenfield Hospital  Leicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,6,16]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"217","volume-title":"Allergy and Allergic Diseases","author":"Bradding P.","year":"2008"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/381075a0"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.02.039"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.54.7.549"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1191\/0960327105ht502oa"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-11-078097"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00091704"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2007.02886.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1119(00)00598-9"},{"key":"e_1_2_6_11_1","doi-asserted-by":"crossref","first-page":"15323","DOI":"10.1016\/S0021-9258(19)84829-9","article-title":"Complete structure of the mouse mast cell receptor for IgE (Fc epsilon RI) and surface expression of chimeric receptors (rat\u2010mouse\u2010human) on transfected cells","volume":"264","author":"Ra C.","year":"1989","journal-title":"J. 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