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We have shown that group VIA phospholipase A\n                    <jats:sub>2<\/jats:sub>\n                    [calcium\u2010independent phospholipase A\n                    <jats:sub>2<\/jats:sub>\n                    \u03b2 (iPLA\n                    <jats:sub>2<\/jats:sub>\n                    \u03b2)] is important in regulating extracellular lysophosphatidic acid (LPA) levels around human epithelial ovarian cancer (EOC) cells. To explore the role of iPLA\n                    <jats:sub>2<\/jats:sub>\n                    \u03b2 in host\u2010tumor cell interactions, we have used immunocompetent iPLA\n                    <jats:sub>2<\/jats:sub>\n                    \u03b2 knockout (iPLA\n                    <jats:sub>2<\/jats:sub>\n                    \u03b2\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    ) mice and the mouse EOC cell line ID8. Tumorigenesis and ascites formation were reduced in iPLA\n                    <jats:sub>2<\/jats:sub>\n                    \u03b2\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice compared with wild\u2010type (WT) mice by more &gt;50% and were reduced further when ID8 cell iPLA\n                    <jats:sub>2<\/jats:sub>\n                    \u03b2 levels were lowered (by&gt;95%) with shRNA. LPA and lysophosphatidylcholine (LPC) levels in the tumor microenvironment were reduced to \u223c80% of WT levels in iPLA\n                    <jats:sub>2<\/jats:sub>\n                    \u03b2\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice. LPA, but not LPC, stimulated ID8 cell migration and invasion with cells in which iPLA\n                    <jats:sub>2<\/jats:sub>\n                    \u03b2 expression had been down\u2010regulated\n                    <jats:italic>in vitro<\/jats:italic>\n                    . LPA, but not LPC, also enhanced\n                    <jats:italic>in vivo<\/jats:italic>\n                    ascites formation (by \u223c5\u2010fold) and tumorigenesis in iPLA\n                    <jats:sub>2<\/jats:sub>\n                    \u03b2\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice. This is the first demonstration of a role for host cell iPLA\n                    <jats:sub>2<\/jats:sub>\n                    \u03b2 in cancer, and these findings suggest that iPLA\n                    <jats:sub>2<\/jats:sub>\n                    \u03b2 is a potential target for developing novel antineoplastic therapeutic strategies.\u2014Li, H., Zhao, Z., Wei, G., Yan, L., Wang, D., Zhang, H., Sandusky, G. E., Turk, J., Xu, Y. Group VIA phospholipase A\n                    <jats:sub>2<\/jats:sub>\n                    in both host and tumor cells is involved in ovarian cancer development.\n                    <jats:italic>FASEB J.<\/jats:italic>\n                    24, 4103\u20134116 (2010).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.10-161356","type":"journal-article","created":{"date-parts":[[2010,6,8]],"date-time":"2010-06-08T22:53:45Z","timestamp":1276037625000},"page":"4103-4116","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Group VIA phospholipase A\n                    <sub>2<\/sub>\n                    in both host and tumor cells is involved in ovarian cancer development"],"prefix":"10.1096","volume":"24","author":[{"given":"Hui","family":"Li","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Indiana University  Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenwen","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Indiana University  Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Indiana University  Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Libo","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Indiana University  Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongmei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Indiana University  Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Indiana University  Indianapolis Indiana USA"},{"name":"Department of Pathology Laboratory Medicine Indiana University  Indianapolis Indiana USA"},{"name":"Department of General Surgery Second Hospital of Jilin University  Changchun Jilin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George Earl","family":"Sandusky","sequence":"additional","affiliation":[{"name":"Department of Pathology Laboratory Medicine Indiana University  Indianapolis Indiana USA"},{"name":"Department of General Surgery Second Hospital of Jilin University  Changchun Jilin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Turk","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, Diabetes, and Metabolism Department of Medicine Washington University School of Medicine  St. Louis Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Indiana University  Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,6,8]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2004.05.003"},{"key":"e_1_2_6_3_1","first-page":"168","article-title":"Novel lipid signaling pathways in ovarian cancer cells","volume":"3","author":"Xu Y.","year":"2006","journal-title":"Cell Sci. 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