{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:50:05Z","timestamp":1791352205762,"version":"4.3.1"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2010,10,19]],"date-time":"2010-10-19T00:00:00Z","timestamp":1287446400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009023","name":"Precursory Research for Embryonic Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009023","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2011,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Acute inflammation in healthy individuals is self\u2010limiting and has an active termination program. The mechanisms by which acute inflammation is resolved are of interest. In murine zymosan\u2010induced peritonitis, we found that eosinophils are recruited to the inflamed loci during the resolution phase of acute inflammation.\n                    <jats:italic>In vivo<\/jats:italic>\n                    depletion of eosinophils caused a resolution deficit, namely impaired lymphatic drainage with reduced appearance of phagocytes carrying engulfed zymosan in the draining lymph node, and sustained numbers of polymorphonuclear leukocytes in inflamed tissues. Liquid chromatography\u2010tandem mass spectrometry\u2010based lipidomics of the resolving exu\u2010dates revealed that locally activated eosinophils in the resolution phase produced proresolving mediators, including protectin D1 (PD1) from docosa\u2010hexaenoic acid. The resolution deficit caused by eosinophil depletion was rescued by eosinophil restoration or the administration of PD1. Eosinophils deficient in 12\/15\u2010lipoxygenase could not rescue the resolution phenotype. The present results indicate that mouse eosinophils and eosinophil\u2010derived lipid mediators, including PD1, have a role in promoting the resolution of acute inflammation, expanding the roles of eosinophils in host defense and resolution.\u2014Yamada, T., Tani, Y., Nakanishi, H., Taguchi, R., Arita, M., Arai, H. Eosinophils promote resolution of acute peritonitis by producing proresolving mediators in mice.\n                    <jats:italic>FASEB J.<\/jats:italic>\n                    25, 561\u2013568 (2011).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.10-170027","type":"journal-article","created":{"date-parts":[[2010,10,19]],"date-time":"2010-10-19T22:52:17Z","timestamp":1287528737000},"page":"561-568","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":131,"title":["Eosinophils promote resolution of acute peritonitis by producing proresolving mediators in mice"],"prefix":"10.1096","volume":"25","author":[{"given":"Tomohiro","family":"Yamada","sequence":"first","affiliation":[{"name":"Department of Health Chemistry Graduate School of Pharmaceutical Sciences University of Tokyo Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukako","family":"Tani","sequence":"additional","affiliation":[{"name":"Department of Health Chemistry Graduate School of Pharmaceutical Sciences University of Tokyo Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Nakanishi","sequence":"additional","affiliation":[{"name":"Department of Metabolome Graduate School of Medicine University of Tokyo Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Taguchi","sequence":"additional","affiliation":[{"name":"Department of Metabolome Graduate School of Medicine University of Tokyo Tokyo Japan"},{"name":"Core Research for Evolutional Science and Technology Japan Science and Technology Agency Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Arita","sequence":"additional","affiliation":[{"name":"Department of Health Chemistry Graduate School of Pharmaceutical Sciences University of Tokyo Tokyo Japan"},{"name":"Precursory Research for Embryonic Science and Technology Japan Science and Technology Agency Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Arai","sequence":"additional","affiliation":[{"name":"Department of Health Chemistry Graduate School of Pharmaceutical Sciences University of Tokyo Tokyo Japan"},{"name":"Core Research for Evolutional Science and Technology Japan Science and Technology Agency Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,10,19]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"1999 W.B. 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