{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T13:51:13Z","timestamp":1775310673918,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2010,10,19]],"date-time":"2010-10-19T00:00:00Z","timestamp":1287446400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2011,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The purpose of this study was to investigate the role of lipoxin A\n                    <jats:sub>4<\/jats:sub>\n                    , an anti\u2010inflammatory and proresolution modulator, during human parturition. We measured serum levels of lipoxin A\n                    <jats:sub>4<\/jats:sub>\n                    and myome\u2010trial protein release using ELISA, quantified lipoxin receptor (FPR2\/ALX) mRNA expression using qRT\u2010PCR, and localized protein expression using immuno\u2010histochemstry in myometrial biopsies from pregnant women. In addition, we compared the effects of lipoxin A\n                    <jats:sub>4<\/jats:sub>\n                    (100 nM) with vehicle on basal and LPS\u2010stimulated expression of proinflammatory cytokines from samples of myometrium from pregnant women. Mean \u00b1\n                    <jats:sc>se<\/jats:sc>\n                    circulating level of lipoxin A\n                    <jats:sub>4<\/jats:sub>\n                    was 5.89 \u00b1 0.63 nM at 24\u2010wk gestation, with a further modest increase during pregnancy (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.05), but no differences in gestation matched women before and after labor (\n                    <jats:italic>P<\/jats:italic>\n                    &gt;0.05). Levels of lipoxin A\n                    <jats:sub>4<\/jats:sub>\n                    in nonpregnant women were 0.48 \u00b1 0.04 nM, significantly lower than in pregnant women (P&lt;0.001). FPR2\/ALX localized to myocytes and neutrophils, with a 9\u2010fold increase in mRNA expression in labor (P&lt;0.001). Lipoxin A\n                    <jats:sub>4<\/jats:sub>\n                    significantly reduced LPS\u2010induced but not basal expression of the proinflammatory cytokines IL\u20106 and IL\u20108 in cultured myometrium (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.05), compared to vehicle\u2010treated controls. We demonstrate for the first time a potential role for lipoxin A\n                    <jats:sub>4<\/jats:sub>\n                    and its receptor in the resolution of the inflammatory events of both physiological and pathological labor.\u2014Maldonado\u2010Perez, D., Golightly, E., Denison, F. C., Jabbour, H. N., Norman, J. E. Arole for lipoxin A\n                    <jats:sub>4<\/jats:sub>\n                    as anti\u2010inflammatory and proresolution mediator in human parturition.\n                    <jats:italic>FASEB J.<\/jats:italic>\n                    25, 569\u2013575 (2011).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.10-170340","type":"journal-article","created":{"date-parts":[[2010,10,19]],"date-time":"2010-10-19T22:52:17Z","timestamp":1287528737000},"page":"569-575","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["A role for lipoxin A\n                    <sub>4<\/sub>\n                    as anti\u2010inflammatory and proresolution mediator in human parturition"],"prefix":"10.1096","volume":"25","author":[{"given":"David","family":"Maldonado\u2010P\u00e9rez","sequence":"first","affiliation":[{"name":"Division of Reproductive and Developmental Sciences University of Edinburgh Edinburgh UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen","family":"Golightly","sequence":"additional","affiliation":[{"name":"Division of Reproductive and Developmental Sciences University of Edinburgh Edinburgh UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fiona C.","family":"Denison","sequence":"additional","affiliation":[{"name":"Division of Reproductive and Developmental Sciences University of Edinburgh Edinburgh UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry N.","family":"Jabbour","sequence":"additional","affiliation":[{"name":"Medical Research Council Human Reproductive Sciences Unit The Queen's Medical Research Institute Edinburgh UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane E.","family":"Norman","sequence":"additional","affiliation":[{"name":"Division of Reproductive and Developmental Sciences University of Edinburgh Edinburgh UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,10,19]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gag001"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/15.1.229"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gap054"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/7.6.581"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1530\/REP-09-0247"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-956773"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2294"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M305841200"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00380.2008"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plefa.2005.05.002"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.109.001578"},{"key":"e_1_2_6_13_1","doi-asserted-by":"crossref","DOI":"10.1096\/fj.10-159913","article-title":"FPR2\/ALX receptor expression and internalization are critical for lipoxin A4 and annexin\u2010derived peptide\u2010stimulated phagocytosis. 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