{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T13:46:07Z","timestamp":1774705567418,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2010,10,26]],"date-time":"2010-10-26T00:00:00Z","timestamp":1288051200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["G0601490"],"award-info":[{"award-number":["G0601490"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2011,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    We postulated that changes in cardiac high\u2010energy phosphate metabolism may underlie the myocardial dysfunction caused by hypobaric hypoxia. Healthy volunteers (\n                    <jats:italic>n<\/jats:italic>\n                    =14) were studied immediately before, and within 4 d of return from, a 17\u2010d trek to Mt. Everest Base Camp (5300 m).\n                    <jats:sup>31<\/jats:sup>\n                    P magnetic resonance (MR) spectroscopy was used to measure cardiac phosphocreatine (PCr)\/ATP, and MR imaging and echocardiography were used to assess cardiac volumes, mass, and function. Immediately after returning from Mt. Everest, total body weight had fallen by 3% (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.05), but left ventricular mass, adjusted for changes in body surface area, had disproportionately decreased by 11% (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.05). Alterations in diastolic function were also observed, with a reduction in peak left ventricular filling rates and mitral inflow E\/A, by 17% (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.05) and 24% (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.01), respectively, with no change in hydration status. Compared with pretrek, cardiac PCr\/ATP ratio had decreased by 18% (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.01). Whether the abnormalities were even greater at altitude is unknown, but all had returned to pretrek levels after 6 mo. The alterations in cardiac morphology, function, and energetics are similar to findings in patients with chronic hypoxia. Thus, a decrease in cardiac PCr\/ATP may be a universal response to periods of sustained low oxygen availability, underlying hypoxia\u2010induced cardiac dysfunction in healthy human heart and in patients with cardiopulmonary diseases.\u2014Holloway, C. J., Montgomery, H. U., Murray, A. J., Cochlin, L. E., Codreanu, I. Hopwood, N., Johnson, A. W., Rider, O. J., Levett, D. Z. H., Tyler, D. J., Francis, J. M., Neubauer, S., Grocott, M. P. W., Clarke, K., for the Caudwell Xtreme Everest Research Group. Cardiac response to hypobaric hypoxia: persistent changes in cardiac mass, function, and energy metabolism after a trek to Mt. Everest Base Camp.\n                    <jats:italic>FASEB J.<\/jats:italic>\n                    25, 792\u2013796 (2011).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.10-172999","type":"journal-article","created":{"date-parts":[[2010,10,26]],"date-time":"2010-10-26T22:47:47Z","timestamp":1288133267000},"page":"792-796","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":88,"title":["Cardiac response to hypobaric hypoxia: persistent changes in cardiac mass, function, and energy metabolism after a trek to Mt. Everest Base Camp"],"prefix":"10.1096","volume":"25","author":[{"given":"Cameron J.","family":"Holloway","sequence":"first","affiliation":[{"name":"Department of Physiology, Anatomy, and Genetics University of Oxford Oxford UK"},{"name":"The University of Oxford Centre for Clinical Magnetic Resonance Research University of Oxford Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugh E.","family":"Montgomery","sequence":"additional","affiliation":[{"name":"University College London (UCL) Centre for Altitude, Space, and Extreme Environment Medicine London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew J.","family":"Murray","sequence":"additional","affiliation":[{"name":"Department of Physiology, Anatomy, and Genetics University of Oxford Oxford UK"},{"name":"The University of Oxford Centre for Clinical Magnetic Resonance Research University of Oxford Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lowri E.","family":"Cochlin","sequence":"additional","affiliation":[{"name":"Department of Physiology, Anatomy, and Genetics University of Oxford Oxford UK"},{"name":"The University of Oxford Centre for Clinical Magnetic Resonance Research University of Oxford Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ion","family":"Codreanu","sequence":"additional","affiliation":[{"name":"The University of Oxford Centre for Clinical Magnetic Resonance Research University of Oxford Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naomi","family":"Hopwood","sequence":"additional","affiliation":[{"name":"Department of Physiology, Anatomy, and Genetics University of Oxford Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew W.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Physiology, Anatomy, and Genetics University of Oxford Oxford UK"},{"name":"The University of Oxford Centre for Clinical Magnetic Resonance Research University of Oxford Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver J.","family":"Rider","sequence":"additional","affiliation":[{"name":"The University of Oxford Centre for Clinical Magnetic Resonance Research University of Oxford Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denny Z. H.","family":"Levett","sequence":"additional","affiliation":[{"name":"University College London (UCL) Centre for Altitude, Space, and Extreme Environment Medicine London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damian J.","family":"Tyler","sequence":"additional","affiliation":[{"name":"Department of Physiology, Anatomy, and Genetics University of Oxford Oxford UK"},{"name":"The University of Oxford Centre for Clinical Magnetic Resonance Research University of Oxford Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane M.","family":"Francis","sequence":"additional","affiliation":[{"name":"The University of Oxford Centre for Clinical Magnetic Resonance Research University of Oxford Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Neubauer","sequence":"additional","affiliation":[{"name":"The University of Oxford Centre for Clinical Magnetic Resonance Research University of Oxford Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael P. W.","family":"Grocott","sequence":"additional","affiliation":[{"name":"University College London (UCL) Centre for Altitude, Space, and Extreme Environment Medicine London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kieran","family":"Clarke","sequence":"additional","affiliation":[{"name":"Department of Physiology, Anatomy, and Genetics University of Oxford Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"for the Caudwell Xtreme Everest Research Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2010,10,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/gm117"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.4.1313"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-006-0299-1"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.161.1.9902096"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.12.007"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200524408"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra063052"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1350"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.20638"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc5921"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-003-0872-9"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1977.42.5.722"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.2000.279.4.H2013"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1580\/07-WEME-OR-094R1.1"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199012063232304"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.3.1215"},{"key":"e_1_2_6_18_1","doi-asserted-by":"crossref","first-page":"H216","DOI":"10.1152\/ajpheart.1996.270.1.H216","article-title":"Developmental changes in ATP utilization during graded hypoxia and reoxygenation in the heart in vivo","volume":"270","author":"Portman M.","year":"1996","journal-title":"Am. 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