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A functional protein, guanosinetriphosphate\u2010binding protein 1 (GTPBP1), which associates with both the exosome and target mRNAs, was identified. The overexpression of GTPBP1 accelerated the target mRNA decay, whereas the reduction of the GTPBP1 expression with RNA interference stabilized the target mRNA. GTPBP1 has a putative guanosinetriphosphate (GTP)\u2010binding domain, which is found in members of the G\u2010protein family and Ski7p, a well\u2010known core factor of the exosome\u2010mediated mRNA turnover pathway in yeast. Analyses of protein interactions and mRNA decay demonstrated that GTPBP1 modulates mRNA degradation\n                      <jats:italic>via<\/jats:italic>\n                      GTP\u2010binding\u2010dependent target loading. Moreover, GTPBP1\u2010knockout models displayed multiple mRNA decay defects, including elevated nocturnal levels of Aanat mRNA in pineal glands, and retarded degradation of TNF\u2010\u03b1 mRNA in lipopolysaccharide\u2010treated splenocytes. The results of this study suggest that GTPBP1 is a regulator and adaptor of the exosome\u2010mediated mRNA turnover pathway.\u2014Woo, K.\u2010C., Kim, T.\u2010D., Lee, K.\u2010H., Kim, D.\u2010Y. Kim, S., Lee, H.\u2010R., Kang, H.\u2010J., Chung, S. J., Senju, S., Nishimura, Yasuharu, Kim, K.\u2010T. Modulation of exosome\u2010mediated mRNA turnover by interaction of GTP\u2010binding protein 1 (GTPBP1) with its target mRNAs.\n                      <jats:italic>FASEB J.<\/jats:italic>\n                      25, 2757\u20102769 (2011).\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1096\/fj.10-178715","type":"journal-article","created":{"date-parts":[[2011,4,22]],"date-time":"2011-04-22T22:04:38Z","timestamp":1303509878000},"page":"2757-2769","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Modulation of exosome\u2010mediated mRNA turnover by interaction of GTP\u2010binding protein 1 (GTPBP1) with its target 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