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We have reported the ability of one such OAK, C\n                    <jats:sub>12<\/jats:sub>\n                    K\u20107\u03b1\n                    <jats:sub>8<\/jats:sub>\n                    , to cluster anionic lipids and to promote a structural change with lipid bilayers to form rolled cylindrical structures or cochleates, without requiring divalent cations for their assembly. These assemblies can be exploited for drug delivery, permitting their synergistic use with antibiotics in systemic therapy to increase efficacy and reduce toxicity. Our previous studies of the biophysical properties of these systems led us to select mixtures with the goal of optimizing their potential for enhancing effectiveness in combating bacterial multidrug resistance. Here, we further investigate the properties of such mixtures that result in enhanced\n                    <jats:italic>in vivo<\/jats:italic>\n                    activity. The role of erythromycin in the assembly of cochleates with OAK in the gel and the liquid crystalline states were assessed, as well as the encapsulation efficiency of the systems chosen. In addition, we found that erythromycin did not undermine the ability of OAKs to induce fusion of vesicles, fusion being an essential component of cochleate formation. The\n                    <jats:italic>in vivo<\/jats:italic>\n                    activity of the new assemblies tested resulted in higher survival rates of animals infected with multidrug resistant bacteria.\u2014Sarig, H., Ohana, D., Epand, R. F., Mor, A., Epand, R. M. Functional studies of cochleate assemblies of an oligo\u2010acyl\u2010lysyl with lipid mixtures for combating bacterial multidrug resistance.\n                    <jats:italic>FASEB J.<\/jats:italic>\n                    25, 3336\u20133343 (2011).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.11-183764","type":"journal-article","created":{"date-parts":[[2011,6,15]],"date-time":"2011-06-15T20:17:04Z","timestamp":1308169024000},"page":"3336-3343","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Functional studies of cochleate assemblies of an oligo\u2010acyl\u2010lysyl with lipid mixtures for combating bacterial multidrug resistance"],"prefix":"10.1096","volume":"25","author":[{"given":"Hadar","family":"Sarig","sequence":"first","affiliation":[{"name":"Department of Biotechnology and Food Engineering Technion\u2010Israel Institute of Technology  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dafna","family":"Ohana","sequence":"additional","affiliation":[{"name":"Department of Biotechnology and Food Engineering Technion\u2010Israel Institute of Technology  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel F.","family":"Epand","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biomedical Sciences McMaster University  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amram","family":"Mor","sequence":"additional","affiliation":[{"name":"Department of Biotechnology and Food Engineering Technion\u2010Israel Institute of Technology  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard M.","family":"Epand","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biomedical Sciences McMaster University  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,6,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.2165\/11317030-000000000-00000"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.78.082907.145923"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05630"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/mr.60.4.575-608.1996"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.8.3630"},{"key":"e_1_2_6_7_1","doi-asserted-by":"crossref","first-page":"3235","DOI":"10.1128\/AAC.00430-07","article-title":"Efflux\u2010related resistance to norfloxacin, dyes, and biocides in bloodstream isolates of Staphylococcus aureus","volume":"51","author":"De Marco C. 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