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The\n                    <jats:italic>B. anthracis<\/jats:italic>\n                    pleiotropic regulator CodY activates toxin gene expression by post\u2010translationally regulating the accumulation of the global regulator AtxA. However, the role of CodY on\n                    <jats:italic>B. anthracis<\/jats:italic>\n                    capsulation and virulence of encapsulated strains has been unknown. The role of CodY in\n                    <jats:italic>B. anthracis<\/jats:italic>\n                    virulence was studied in mouse and guinea pig models. Spore outgrowth and dissemination of the vegetative cells was followed in mice by bioluminescent imaging. We also determined the state of capsulation and the iron requirement for growth of the\n                    <jats:italic>codY<\/jats:italic>\n                    mutant. In all models tested, the\n                    <jats:italic>codY<\/jats:italic>\n                    mutant strain was strongly attenuated compared to the wild\u2010type strain and, in mice, also compared to the\n                    <jats:italic>atxA<\/jats:italic>\n                    strain. The disruption of\n                    <jats:italic>codY<\/jats:italic>\n                    did not affect either\n                    <jats:italic>ex vivo<\/jats:italic>\n                    or\n                    <jats:italic>in vivo<\/jats:italic>\n                    capsulation, whereas\n                    <jats:italic>atxA<\/jats:italic>\n                    deletion affected\n                    <jats:italic>ex vivo<\/jats:italic>\n                    capsulation only. The disruption of\n                    <jats:italic>codY<\/jats:italic>\n                    led to a delayed initiation of dissemination but similar kinetics of subsequent spread of the bacilli. The\n                    <jats:italic>codY<\/jats:italic>\n                    mutant cannot grow on heme iron as sole iron source, whereas the parental and complemented strains can. The lack of CodY\u2010mediated transcription weakens virulence by controlling iron acquisition and synthesis of toxin, but without modifying capsulation.\u2014Ch\u00e2teau, A., van Schaik, W., Six, A., Aucher, W., Fouet, A. CodY regulation is required for full virulence and heme iron acquisition in\n                    <jats:italic>Bacillus anthracis<\/jats:italic>\n                    .\n                    <jats:italic>FASEB J.<\/jats:italic>\n                    25, 4445\u20134456 (2011).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.11-188912","type":"journal-article","created":{"date-parts":[[2011,9,13]],"date-time":"2011-09-13T02:42:27Z","timestamp":1315881747000},"page":"4445-4456","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["CodY regulation is required for full virulence and heme iron acquisition in\n                    <i>Bacillus anthracis<\/i>"],"prefix":"10.1096","volume":"25","author":[{"given":"Alice","family":"Ch\u00e2teau","sequence":"first","affiliation":[{"name":"Unit\u00e9 des Toxines et Pathog\u00e9nie Bact\u00e9riennes  Paris France"},{"name":"Laboratoire Pathog\u00e9nie des Toxi\u2010Infections Bact\u00e9riennes Institut Pasteur  Paris France"},{"name":"Centre National de la Recherche Scientifique (CNRS)  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willem","family":"van Schaik","sequence":"additional","affiliation":[{"name":"Unit\u00e9 des Toxines et Pathog\u00e9nie Bact\u00e9riennes  Paris France"},{"name":"Centre National de la Recherche Scientifique (CNRS)  Paris France"},{"name":"Department of Medical Microbiology University Medical Center Utrecht  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Six","sequence":"additional","affiliation":[{"name":"Unit\u00e9 des Toxines et Pathog\u00e9nie Bact\u00e9riennes  Paris France"},{"name":"Laboratoire Pathog\u00e9nie des Toxi\u2010Infections Bact\u00e9riennes Institut Pasteur  Paris France"},{"name":"Current address: Institut Cochin, Barriers and Pathogens Universit\u00e9 Paris Descartes, INSERM U567, CNRS UMR 8104  75014 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willy","family":"Aucher","sequence":"additional","affiliation":[{"name":"Unit\u00e9 des Toxines et Pathog\u00e9nie Bact\u00e9riennes  Paris France"},{"name":"Centre National de la Recherche Scientifique (CNRS)  Paris France"},{"name":"Current address: G\u00e9n\u00e9tique Mol\u00e9culaire Institut Pasteur  75015 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agn\u00e8s","family":"Fouet","sequence":"additional","affiliation":[{"name":"Laboratoire Pathog\u00e9nie des Toxi\u2010Infections Bact\u00e9riennes Institut Pasteur  Paris France"},{"name":"Centre National de la Recherche Scientifique (CNRS)  Paris France"},{"name":"Institut Cochin, Barriers and Pathogens, INSERM U\u20101016  Paris France"},{"name":"CNRS UMR\u20108104  Paris France"},{"name":"Universit\u00e9 Paris Descartes Sorbonne Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,9,12]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"341","article-title":"Experimentelle Studien \u00fcber Virulenz, Empf\u00e4nglichkeit und Immunit\u00e4t beim Milzbrand","volume":"5","author":"Preisz H.","year":"1909","journal-title":"Zeitschr. 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