{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T11:56:38Z","timestamp":1791028598315,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,9,29]],"date-time":"2011-09-29T00:00:00Z","timestamp":1317254400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Ghrelin is a unique peptide gut hormone that requires post\u2010translational modification to stimulate both feeding and growth hormone release. Ghrelin\n                    <jats:italic>O<\/jats:italic>\n                    \u2010acyltransferase (GOAT) was identified as a specific acyl\u2010transferase for ghrelin, and recent genetic deletion studies of the\n                    <jats:italic>Goat<\/jats:italic>\n                    gene (\n                    <jats:italic>\n                      Goat\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    <\/jats:italic>\n                    ) uncovered the role of ghrelin in the regulation of glucose homeostasis. To further understand the physiological functions of the GOAT\/ghrelin system, we have conducted a metabolomic and microarray profile of\n                    <jats:italic>Goat<\/jats:italic>\n                    \u2010null mice, as well as determined\n                    <jats:italic>Goat<\/jats:italic>\n                    expression in different tissues using the\n                    <jats:italic>lacZ<\/jats:italic>\n                    reporter gene. Serum metabolite profile analysis revealed that\n                    <jats:italic>\n                      Goat\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    <\/jats:italic>\n                    mice exhibited increased secondary bile acids &gt;2.5\u2010fold. This was attributed to increased mRNA and protein expression of the ileal sodium\u2010dependent bile acid transporter (ISBT) in the intestinal and biliary tract. Increased expression of additional solute carrier proteins, including\n                    <jats:italic>Slc5a12<\/jats:italic>\n                    (&gt;10\u2010fold) were also detected in the small intestine and bile duct.\n                    <jats:italic>Goat<\/jats:italic>\n                    staining was consistently observed in the pituitary glands, stomach, and intestines, and to a lesser extent in the gallbladder and pancreatic duct. This is the first report that the GOAT\/ghrelin system regulates bile acid metabolism, and these findings suggest a novel function of GOAT in the regulation of intestinal bile acid reabsorption.\u2014Kang, K., Schmahl, J., Lee, J. \u2010M., Garcia, K., Patil, K., Chen, A., Keene, M., Murphy, A., Sleeman, M. W. Mouse ghrelin\u2010\n                    <jats:italic>O<\/jats:italic>\n                    \u2010acyltransferase (GOAT) plays a critical role in bile acid reabsorption.\n                    <jats:italic>FASEB J.<\/jats:italic>\n                    26, 259\u2013271 (2012).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.11-191460","type":"journal-article","created":{"date-parts":[[2011,9,30]],"date-time":"2011-09-30T07:18:30Z","timestamp":1317367110000},"page":"259-271","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Mouse ghrelin\u2010\n                    <i>O<\/i>\n                    \u2010acyltransferase (GOAT) plays a critical role in bile acid reabsorption"],"prefix":"10.1096","volume":"26","author":[{"given":"Kihwa","family":"Kang","sequence":"first","affiliation":[{"name":"Regeneron Pharmaceuticals  Tarrytown New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Schmahl","sequence":"additional","affiliation":[{"name":"Regeneron Pharmaceuticals  Tarrytown New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong\u2010Min","family":"Lee","sequence":"additional","affiliation":[{"name":"Center for Human Genetic Research Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Garcia","sequence":"additional","affiliation":[{"name":"Regeneron Pharmaceuticals  Tarrytown New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ketan","family":"Patil","sequence":"additional","affiliation":[{"name":"Regeneron Pharmaceuticals  Tarrytown New York 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