{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T05:42:37Z","timestamp":1792129357497,"version":"4.4.0"},"reference-count":84,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,9,22]],"date-time":"2011-09-22T00:00:00Z","timestamp":1316649600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Anomalous neuritogenesis is a hallmark of neurodegenerative disorders, including retinal degenerations, epilepsy, and Alzheimer's disease. The neuritogenesis processes result in a partial reinnervation, new circuitry, and functional changes within the deafferented retina and brain regions. Using the light\u2010induced retinal degeneration (LIRD) mouse model, which provides a unique platform for exploring the mechanisms underlying neuritogenesis, we found that retinoid X receptors (RXRs) control neuritogenesis. LIRD rapidly triggered retinal neuron neuritogenesis and up\u2010regulated several key elements of retinoic acid (RA) signaling, including retinoid X receptors (RXRs). Exogenous RA initiated neuritogenesis in normal adult retinas and primary retinal cultures and exacerbated it in LIRD retinas. However, LIRD\u2010induced neuritogenesis was partly attenuated in retinol dehydrogenase knockout (\n                    <jats:italic>\n                      Rdh12\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    <\/jats:italic>\n                    ) mice and by aldehyde dehydrogenase inhibitors. We further found that LIRD rapidly increased the expression of glutamate receptor 2 and \u03b2 Ca\n                    <jats:sup>2+<\/jats:sup>\n                    \/ calmodulin\u2010dependent protein kinase II (pCaMKII). Pulldown assays demonstrated interaction between PCaMKII and RXRs, suggesting that CaMKII pathway regulates the activities of RXRs. RXR antagonists completely prevented and RXR agonists were more effective than RA in inducing neuritogenesis. Thus, RXRs are in the final common path and may be therapeutic targets to attenuate retinal remodeling and facilitate global intervention methods in blinding diseases and other neurodegenerative disorders.\u2014Lin, Y., Jones, B. W., Liu, A., Tucker, J. F., Rapp, K., Luo, L., Baehr, W., Bernstein, P. S., Watt, C. B., Yang, J.\u2010H., Shaw, M. V., Marc, R. E. Retinoid receptors trigger neuritogenesis in retinal degenerations.\n                    <jats:italic>FASEB J.<\/jats:italic>\n                    26, 81\u201392 (2012).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.11-192914","type":"journal-article","created":{"date-parts":[[2011,9,23]],"date-time":"2011-09-23T03:59:27Z","timestamp":1316750367000},"page":"81-92","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Retinoid receptors trigger neuritogenesis in retinal degenerations"],"prefix":"10.1096","volume":"26","author":[{"given":"Yanhua","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Ophthalmology John A. Moran Eye Center, School of Medicine  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan W.","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology John A. Moran Eye Center, School of Medicine  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aihua","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology John A. Moran Eye Center, School of Medicine  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James F.","family":"Tucker","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology John A. Moran Eye Center, School of Medicine  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Rapp","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology John A. Moran Eye Center, School of Medicine  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology John A. Moran Eye Center, School of Medicine  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Baehr","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology John A. Moran Eye Center, School of Medicine  Salt Lake City Utah USA"},{"name":"Department of Neurobiology and Anatomy Health Science Center  Salt Lake City Utah USA"},{"name":"Department of Biology University of Utah  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul S.","family":"Bernstein","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology John A. Moran Eye Center, School of Medicine  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl B.","family":"Watt","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology John A. Moran Eye Center, School of Medicine  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia\u2010Hui","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology John A. Moran Eye Center, School of Medicine  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marguerite V.","family":"Shaw","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology John A. Moran Eye Center, School of Medicine  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert E.","family":"Marc","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology John A. 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