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This study aimed to determine whether MRP proteins regulate cardiac cAMP homeostasis. Here, we demonstrate that MRP4 is the predominant isoform present at the plasma membrane of cardiacmyocytes and that it mediates the efflux of cAMP in these cells. MRP4\u2010deficient mice displayed enhanced cardiac myocyte cAMP formation, contractility, and cardiac hypertrophy at 9 mo of age, an effect that was compensated transiently by increased phosphodiesterase expression at young age. These findings suggest that cAMP extrusion\n                    <jats:italic>via<\/jats:italic>\n                    MRP4 acts together with phosphodiesterases to control cAMP levels in cardiac myocytes.\u2014Sassi, Y., Abi\u2010Gerges, A., Fauconnier, J., Mougenot, N., Reiken, S., Haghighi, K., Kranias, E. G., Marks, A. R., Lacampagne, A., Engelhardt, S., Hatem, S. N., Lompre, A.\u2010M., Hulot, J. S. Regulation of cAMP homeostasis by the efflux protein MRP4 in cardiac myocytes.\n                    <jats:italic>FASEB J.<\/jats:italic>\n                    26, 1009\u20101017 (2012).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.11-194027","type":"journal-article","created":{"date-parts":[[2011,11,17]],"date-time":"2011-11-17T07:39:19Z","timestamp":1321515559000},"page":"1009-1017","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":71,"title":["Regulation of cAMP homeostasis by the efflux protein MRP4 in cardiac myocytes"],"prefix":"10.1096","volume":"26","author":[{"given":"Yassine","family":"Sassi","sequence":"first","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM)\/Universit\u00e9 Pierre et Marie Curie Unit\u00e9 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