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We examined whether functional\n                    <jats:italic>MIF<\/jats:italic>\n                    gene polymorphisms (\u2013794 CATT\n                    <jats:sub>5\u20138<\/jats:sub>\n                    microsatellite and \u2013173 G\/C SNP) were associated with the occurrence and outcome of meningococcal disease in children. The CATT\n                    <jats:sub>5<\/jats:sub>\n                    allele was associated with the probability of death predicted by the Pediatric Index of Mortality 2 (\n                    <jats:italic>P<\/jats:italic>\n                    =0.001), which increased in correlation with the CATT\n                    <jats:sub>5<\/jats:sub>\n                    copy number (\n                    <jats:italic>P<\/jats:italic>\n                    =0.04). The CATT\n                    <jats:sub>5<\/jats:sub>\n                    allele, but not the \u2014173 G\/C alleles, was also associated with the actual mortality from meningoccal sepsis [OR 2.72 (1.2\u20106.4),\n                    <jats:italic>P<\/jats:italic>\n                    =0.02]. A family\u2010based association test (\n                    <jats:italic>i.e.<\/jats:italic>\n                    , transmission disequilibrium test) performed in 240 trios with 1 afflicted offspring indicated that CATT\n                    <jats:sub>5<\/jats:sub>\n                    was a protective allele (\n                    <jats:italic>P<\/jats:italic>\n                    =0.02) for the occurrence of meningococcal disease. At baseline and after stimulation with\n                    <jats:italic>Neisseria meningitidis<\/jats:italic>\n                    in THP\u20101 monocytic cells or in a whole\u2010blood assay, CATT\n                    <jats:sub>5<\/jats:sub>\n                    was found to be a low\u2010expression\n                    <jats:italic>MIF<\/jats:italic>\n                    allele (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.005 and\n                    <jats:italic>P<\/jats:italic>\n                    =0.04 for transcriptional activity;\n                    <jats:italic>P<\/jats:italic>\n                    =0.09 and\n                    <jats:italic>P<\/jats:italic>\n                    =0.09 for MIF production). Taken together, these data suggest that polymorphisms of the\n                    <jats:italic>MIF<\/jats:italic>\n                    gene affecting MIF expression are associated with the occurrence, severity, and outcome of meningococcal disease in children.\u2014Renner, P., Roger, T., Bochud, P.\u2010Y., Sprong, T., Sweep, F. C. G. J., Bochud, M., Faust, S. N., Haralambous, E., Betts, H., Chanson, A.\u2010L., Reymond, M. K., Mermel, E., Erard, V., van Deuren, M., Read, R. C., Levin, M., Calandra, T. A functional microsatellite of the\n                    <jats:italic>macrophage migration inhibitory factor<\/jats:italic>\n                    gene associated with meningococcal disease.\n                    <jats:italic>FASEB J.<\/jats:italic>\n                    26, 907\u2013916 (2012). www.fasebj.org\n                  <\/jats:p>","DOI":"10.1096\/fj.11-195065","type":"journal-article","created":{"date-parts":[[2011,10,12]],"date-time":"2011-10-12T00:19:36Z","timestamp":1318378776000},"page":"907-916","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["A functional microsatellite of the\n                    <i>macrophage migration inhibitory factor<\/i>\n                    gene associated with meningococcal disease"],"prefix":"10.1096","volume":"26","author":[{"given":"Pascal","family":"Renner","sequence":"first","affiliation":[{"name":"Infectious Diseases Service, Department of Medicine Centre Hospitalier Universitaire Vaudois and University of Lausanne  Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thierry","family":"Roger","sequence":"additional","affiliation":[{"name":"Infectious Diseases Service, Department of Medicine Centre Hospitalier Universitaire Vaudois and University of Lausanne  Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre\u2010Yves","family":"Bochud","sequence":"additional","affiliation":[{"name":"Infectious Diseases Service, Department of Medicine Centre Hospitalier Universitaire Vaudois and University of Lausanne  Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom","family":"Sprong","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Inflammation, and Immunity (N4I)"},{"name":"Nijmegen Institute for Infection, Inflammation, and Immunity (N4I)"},{"name":"Department of Internal Medicine Canisius\u2010Wilhelmina Ziekenhuis Nijmegen  Nijmegen The Netherlands"},{"name":"Department of Medical Microbiology Canisius\u2010Wilhelmina Ziekenhuis Nijmegen  Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fred C. G. J.","family":"Sweep","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Radboud University Nijmegen Medical Centre  Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murielle","family":"Bochud","sequence":"additional","affiliation":[{"name":"Institute for Social and Preventive Medicine Centre Hospitalier Universitaire Vaudois and University of Lausanne  Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saul N.","family":"Faust","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Southampton  Southampton UK"},{"name":"University Hospital Southampton National Health Service Foundation Trust  Southampton UK"},{"name":"Wellcome Trust Clinical Research Facility  Southampton UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elene","family":"Haralambous","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Department of Medicine Imperial College London St. Mary's Campus  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen","family":"Betts","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine Imperial College London St. Mary's Campus  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne\u2010Laure","family":"Chanson","sequence":"additional","affiliation":[{"name":"Infectious Diseases Service, Department of Medicine Centre Hospitalier Universitaire Vaudois and University of Lausanne  Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marlies Knaup","family":"Reymond","sequence":"additional","affiliation":[{"name":"Infectious Diseases Service, Department of Medicine Centre Hospitalier Universitaire Vaudois and University of Lausanne  Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elliot","family":"Mermel","sequence":"additional","affiliation":[{"name":"Infectious Diseases Service, Department of Medicine Centre Hospitalier Universitaire Vaudois and University of Lausanne  Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronique","family":"Erard","sequence":"additional","affiliation":[{"name":"Infectious Diseases Service, Department of Medicine Centre Hospitalier Universitaire Vaudois and University of Lausanne  Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcel","family":"van Deuren","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Inflammation, and Immunity (N4I)"},{"name":"Nijmegen Institute for Infection, Inflammation, and Immunity (N4I)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert 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