{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T13:10:33Z","timestamp":1790687433958,"version":"4.1.0"},"reference-count":69,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,2,27]],"date-time":"2012-02-27T00:00:00Z","timestamp":1330300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004085","name":"Ministry of Education, Science and Technology","doi-asserted-by":"publisher","award":["20090081466"],"award-info":[{"award-number":["20090081466"]}],"id":[{"id":"10.13039\/501100004085","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:p>\n                    Although preconditioning injury on the peripheral nerve induces axonal regenerative capacity in neurons, it is not known whether similar lesion effects occur in glial cells. Here we demonstrate that Schwann cells are activated by peripheral nerve preinjury and primed to mediate axon regeneration. Cdc2, which was induced from Schwann cells after sciatic nerve injury, phosphorylated vimentin almost exclusively in the distal nerve area. Phospho\u2010vimentin\u2010positive Schwann cells showed increased migration activity and were in close contact with process outgrowth of co\u2010cultured neurons. Vimentin phosphorylation by Cdc2 was involved in \u03b21\u2010integrin activation leading to FAK phoshorylation and associated with Erk1\/2 activation in Schwann cells. Neurite outgrowth of dorsal root ganglion neurons was increased by co\u2010culture with activated Schwann cells, in which phospho\u2010vimentin signaling was transmitted into \u03b21\u2010integrin activation. Then neurite outgrowth was suppressed by genetic depletion of phospho\u2010vimentin and \u03b21 integrin as well as inhibition of vimentin phosphorylation by Cdc2 inhibitor purvalanol A. The sciatic nerve graft harboring activated Schwann cells into the spinal cord induced Schwann cell migration beyond the graft\u2010host barrier and facilitated regeneration of spinal axons, which was inhibited by purvalanol A pretreatment of the graft. This is the first report to our knowledge demonstrating that activation of phospho\u2010vimentin linked to \u03b21\u2010integrin pathway may mediate transcellular signaling to promote axon growth.\u2014Chang, I. A., Oh, M.\u2010J., Kim, M. H., Park, S.\u2010K., Kim, B. G., Namgung, U. Vimentin phosphorylation by Cdc2 in Schwann cell controls axon growth\n                    <jats:italic>via<\/jats:italic>\n                    \u03b21\u2010integrin activation.\n                    <jats:italic>FASEB J.<\/jats:italic>\n                    26, 2401\u20102413 (2012).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.11-199018","type":"journal-article","created":{"date-parts":[[2012,2,28]],"date-time":"2012-02-28T00:24:09Z","timestamp":1330388649000},"page":"2401-2413","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Vimentin phosphorylation by Cdc2 in Schwann cell controls axon growth\n                    <i>via<\/i>\n                    \u03b21\u2010integrin activation"],"prefix":"10.1096","volume":"26","author":[{"given":"In Ae","family":"Chang","sequence":"first","affiliation":[{"name":"Department of Oriental Medicine Daejeon University Daejeon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myung\u2010Jin","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Oriental Medicine Daejeon University Daejeon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Hee","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Oriental Medicine Daejeon University Daejeon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung\u2010Kiel","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Biochemistry College of Medicine Chungnam National University Daejeon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byung G.","family":"Kim","sequence":"additional","affiliation":[{"name":"Brain Disease Research Center Institute for Medical Sciences Ajou University School of Medicine Suwon Korea"},{"name":"Department of Neurology Ajou University School of Medicine Suwon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uk","family":"Namgung","sequence":"additional","affiliation":[{"name":"Department of Oriental Medicine Daejeon University Daejeon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,2,27]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"191","article-title":"Vimentin, the 57,000 molecular weight protein of fibroblast filaments, is the major cytoskeletal component in immature glia","volume":"24","author":"Dahl D.","year":"1981","journal-title":"Eur. 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