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However, their roles in hypothalamus, and the specific functions of their different receptors, have not been elucidated. Here, we investigated the expression and function of the activin receptor ALK7 in the female reproductive axis using\n                    <jats:italic>Alk7<\/jats:italic>\n                    \u2010knockout mice. ALK7 was found in subsets of SF1\u2010expressing granulosa cells in the ovary, FSH gonadotrophs in the pituitary, and NPY\u2010expressing neurons in the arcuate nucleus of the hypothalamus.\n                    <jats:italic>Alk7<\/jats:italic>\n                    \u2010knockout females showed delayed onset of puberty and abnormal estrous cyclicity, had abnormal diestrous levels of FSH and LH in serum, and their ovaries showed premature depletion of follicles, oocyte degeneration, and impaired responses to exogenous gonadotropins. In the arcuate nucleus, mutant mice showed reduced expression of\n                    <jats:italic>Npy<\/jats:italic>\n                    mRNA and lower numbers of\n                    <jats:italic>Npy<\/jats:italic>\n                    \u2010expressing neurons than wild\u2010type controls.\n                    <jats:italic>Alk7<\/jats:italic>\n                    knockouts showed a selective loss of arcuate NPY\/AgRP innervation in the medial preoptic area, a key central regulator of reproduction. These results indicate that ALK7 is an important regulator of female reproductive function and reveal a new role for activin signaling in the control of hypothalamic gene expression and wiring.\n                    <jats:italic>Alk7<\/jats:italic>\n                    gene variants may contribute to female reproductive disorders in humans, such as polycystic ovary syndrome.\u2014Sandoval\u2010Guzm\u00e1n, T., G\u00f6ngrich, C., Moliner, A., Guo, T., Wu, H., Broberger, C., Ib\u00e1\u00f1ez, C. F. Neuroendocrine control of female reproductive function by the activin receptor ALK7.\n                    <jats:italic>FASEB J.<\/jats:italic>\n                    26, 4966\u20134976 (2012).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.11-199059","type":"journal-article","created":{"date-parts":[[2012,9,6]],"date-time":"2012-09-06T20:18:41Z","timestamp":1346962721000},"page":"4966-4976","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Neuroendocrine control of female reproductive function by the activin receptor ALK7"],"prefix":"10.1096","volume":"26","author":[{"given":"Tatiana","family":"Sandoval\u2010Guzm\u00e1n","sequence":"first","affiliation":[{"name":"Department of Neuroscience Karolinska Institute Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"G\u00f6ngrich","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Karolinska Institute Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalena","family":"Moliner","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Karolinska Institute Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingqing","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Karolinska Institute Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiya","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Karolinska Institute Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Broberger","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Karolinska Institute Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos F.","family":"Ib\u00e1\u00f1ez","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Karolinska Institute Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,9,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(71)80019-0"},{"key":"e_1_2_7_3_1","first-page":"1","article-title":"Chemical and biological characterization of the inhibin family of protein hormones","volume":"44","author":"Vale W.","year":"1988","journal-title":"Recent Progr. 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