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Transmitted by mosquitoes in warmer climatic zones, it is spreading across southern Europe and the Americas at an alarming pace. There is no vaccine, and chemotherapy is prone to complications. To learn more about this parasite, we have sequenced the genomes of\n                    <jats:italic>D. immitis<\/jats:italic>\n                    and its endosymbiont\n                    <jats:italic>Wolbachia.<\/jats:italic>\n                    We predict 10,179 protein coding genes in the 84.2 Mb of the nuclear genome, and 823 genes in the 0.9\u2010Mb\n                    <jats:italic>Wolbachia<\/jats:italic>\n                    genome. The\n                    <jats:italic>D. immitis<\/jats:italic>\n                    genome harbors neither DNA transposons nor active retrotransposons, and there is very little genetic variation between two sequenced isolates from Europe and the United States. The differential presence of anabolic pathways such as heme and nucleotide biosynthesis hints at the intricate metabolic interrelationship between the heartworm and\n                    <jats:italic>Wolbachia.<\/jats:italic>\n                    Comparing the proteome of\n                    <jats:italic>D. immitis<\/jats:italic>\n                    with other nematodes and with mammalian hosts, we identify families of potential drug targets, immune modulators, and vaccine candidates. This genome sequence will support the development of new tools against dirofilariasis and aid efforts to combat related human pathogens, the causative agents of lymphatic filariasis and river blindness.\u2014Godel, C., Kumar, S., Koutsovoulos, G., Ludin, P., Nilsson, D., Comandatore, F., Wrobel, N., Thompson, M., Schmid, C. D., Goto, S., Bringaud, F., Wolstenholme, A., Bandi, C., Epe, C., Kaminsky, R., Blaxter, M., M\u00e4ser, P. The genome of the heartworm,\n                    <jats:italic>Dirofilaria immitis<\/jats:italic>\n                    , reveals drug and vaccine targets.\n                    <jats:italic>FASEB J.<\/jats:italic>\n                    26, 4650\u20134661 (2012).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.12-205096","type":"journal-article","created":{"date-parts":[[2012,8,13]],"date-time":"2012-08-13T22:37:15Z","timestamp":1344897435000},"page":"4650-4661","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":135,"title":["The genome of the heartworm,\n                    <i>Dirofilaria immitis<\/i>\n                    , reveals drug and vaccine 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