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Here, we show that targeted disruption of the novel gene\n                    <jats:italic>Rnase10<\/jats:italic>\n                    encoding a secreted proximal epididymal protein in the mouse results in a binding defect in spermatozoa and their inability to pass through the uterotubal junction in the female. The failure to gain the site of fertilization in the knockout spermatozoa is associated with a gradual loss of ADAM3 and ADAM6 proteins during epididymal transit. In the distal epididymis, these spermatozoa appear to lack calcium\u2010dependent associations with the immobilizing glutinous extracellular material and are released as single, vigorously motile cells that display no tendency for head\u2010to\u2010head agglutination and lack affinity to the oviductal epithelium. In sperm\u2010egg binding assay, they are unable to establish a tenacious association with the zona pellucida, yet they are capable of fertilization. Furthermore, these sperm show accelerated capacitation resulting in an overall\n                    <jats:italic>in vitro<\/jats:italic>\n                    fertilizing ability superior to that of wild\u2010type sperm. We conclude that the physiological role of sperm adhesiveness is in the mechanism of restricted sperm entry into the oviduct rather than in sperm\u2010egg interaction.\u2014Krutskikh, A., Poliandri, A., Cabrera\u2010Sharp, V., Dacheux, J. L., Poutanen, M., Huhtaniemi, I. Epididymal protein Rnase10 is required for post\u2010testicular sperm maturation and male fertility.\n                    <jats:italic>FASEB J.<\/jats:italic>\n                    26, 4198\u20134209 (2012).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.12-205211","type":"journal-article","created":{"date-parts":[[2012,6,29]],"date-time":"2012-06-29T23:07:56Z","timestamp":1341011276000},"page":"4198-4209","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":63,"title":["Epididymal protein Rnase10 is required for post\u2010testicular sperm maturation and male fertility"],"prefix":"10.1096","volume":"26","author":[{"given":"Anton","family":"Krutskikh","sequence":"first","affiliation":[{"name":"Department of Surgery and Cancer Imperial College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariel","family":"Poliandri","sequence":"additional","affiliation":[{"name":"Department of Surgery and Cancer Imperial College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Cabrera\u2010Sharp","sequence":"additional","affiliation":[{"name":"Department of Surgery and Cancer Imperial College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Louis","family":"Dacheux","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Mixte de Recherche Institut National de la Recherche Agronomique Centre National de la Recherche Scientifique Nouzilly France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matti","family":"Poutanen","sequence":"additional","affiliation":[{"name":"Department of Physiology The University of Turku Turku Finland"},{"name":"Turku Center for Disease Modeling The University of Turku Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilpo","family":"Huhtaniemi","sequence":"additional","affiliation":[{"name":"Department of Surgery and Cancer Imperial College London London UK"},{"name":"Department of Physiology The University of Turku Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,6,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1017\/S146479310300633X"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M204596200"},{"key":"e_1_2_7_4_1","first-page":"2074","article-title":"Epididymis seleno\u2010independent glutathione peroxidase 5 maintains sperm DNA integrity in mice","volume":"119","author":"Chabory E.","year":"2009","journal-title":"J. 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