{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T04:08:43Z","timestamp":1770437323619,"version":"3.49.0"},"reference-count":33,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2012,4,2]],"date-time":"2012-04-02T00:00:00Z","timestamp":1333324800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Individuals with a spinal cord injury (SCI), especially with tetraplegia, experience poor sleep quality, and this may be related to impaired control of circadian rhythmicity. Here, we examined the evening onset of melatonin secretion, an important hormone for the initiation of sleep, in people with a complete cervical (tetraplegia) and thoracic (paraplegia) SCI, and age\u2010 and sex\u2010matched able\u2010bodied control participants. Multiple samples of salivary melatonin were obtained during the evening hours and analyzed by ELISA methods in 10 control partcipants, 9 individuals with paraplegia, and 6 individuals with tetraplegia. Sleep quality was assessed using questionnaires. Interactive effects of group and time were found for melatonin levels (\n                    <jats:italic>P<\/jats:italic>\n                    =0.022). In the control and paraplegia groups, the mean melatonin level increased significantly from 2.59 \u00b1 1.04 and 4.28 \u00b1 3.28 pg\/ml at 7 PM to 10.62 \u00b1 4.59 and 13.10 \u00b1 7.39 pg\/ml at 11 PM, respectively (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.001). In the tetraplegia group, melatonin level was 5.25 \u00b1 3.72 at 7 PM but only 2.41 \u00b1 1.25 pg\/ml at 11 PM (\n                    <jats:italic>P<\/jats:italic>\n                    &gt;0.05). Decreased sleep quality was more prevalent in individuals with tetraplegia (83%) and paraplegia (75%) compared with controls (20%;\n                    <jats:italic>P<\/jats:italic>\n                    = 0.02). Unlike in the control and paraplegia groups, the evening increase in melatonin concentration was completely absent in the tetraplegia group. This provides biological insight into sleep regulation in humans and provides better understanding of the poor sleep quality in people with tetraplegia.\u2014Verheggen, R. J., Jones, H., Nyakayiru, J., Thompson, A., Groothuis, J. T., Atkinson, G., Hopman, M. T., Thijssen, D. H. Complete absence of evening melatonin increase in tetraplegics.\n                    <jats:italic>FASEB J.<\/jats:italic>\n                    26, 3059\u20133064 (2012).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.12-205401","type":"journal-article","created":{"date-parts":[[2012,4,3]],"date-time":"2012-04-03T01:10:57Z","timestamp":1333415457000},"page":"3059-3064","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Complete absence of evening melatonin increase in tetraplegics"],"prefix":"10.1096","volume":"26","author":[{"given":"Rebecca J. H. M.","family":"Verheggen","sequence":"first","affiliation":[{"name":"Department of Physiology Radboud University Nijmegen Medical Centre  Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen","family":"Jones","sequence":"additional","affiliation":[{"name":"Research Institute for Sport and Exercise Science Liverpool John Moores University  Liverpool UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean","family":"Nyakayiru","sequence":"additional","affiliation":[{"name":"Department of Physiology Radboud University Nijmegen Medical Centre  Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Thompson","sequence":"additional","affiliation":[{"name":"Research Institute for Sport and Exercise Science Liverpool John Moores University  Liverpool UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan T.","family":"Groothuis","sequence":"additional","affiliation":[{"name":"Department of Physiology Radboud University Nijmegen Medical Centre  Nijmegen The Netherlands"},{"name":"Department of Rehabilitation St. Maartenskliniek  Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Greg","family":"Atkinson","sequence":"additional","affiliation":[{"name":"Research Institute for Sport and Exercise Science Liverpool John Moores University  Liverpool UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria T. E.","family":"Hopman","sequence":"additional","affiliation":[{"name":"Department of Physiology Radboud University Nijmegen Medical Centre  Nijmegen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dick H. J.","family":"Thijssen","sequence":"additional","affiliation":[{"name":"Department of Physiology Radboud University Nijmegen Medical Centre  Nijmegen The Netherlands"},{"name":"Research Institute for Sport and Exercise Science Liverpool John Moores University  Liverpool UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,4,2]]},"reference":[{"key":"e_1_2_17_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.sc.3101197"},{"key":"e_1_2_17_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/apmr.2000.9398"},{"key":"e_1_2_17_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.sc.3101784"},{"key":"e_1_2_17_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2826.2003.00989.x"},{"key":"e_1_2_17_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2004.08.001"},{"key":"e_1_2_17_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2006.06.020"},{"key":"e_1_2_17_8_1","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2010.00137","article-title":"Timing of sleep and its relationship with the endogenous melatonin rhythm","volume":"1","author":"Sletten T. 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P.","year":"2011","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."}],"container-title":["The FASEB Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.12-205401","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1096\/fj.12-205401","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.12-205401","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T17:13:00Z","timestamp":1761671580000},"score":1,"resource":{"primary":{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/10.1096\/fj.12-205401"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4,2]]},"references-count":33,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["10.1096\/fj.12-205401"],"URL":"https:\/\/doi.org\/10.1096\/fj.12-205401","archive":["Portico"],"relation":{},"ISSN":["0892-6638","1530-6860"],"issn-type":[{"value":"0892-6638","type":"print"},{"value":"1530-6860","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4,2]]},"assertion":[{"value":"2012-02-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-03-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-04-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}