{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:00:35Z","timestamp":1791644435408,"version":"4.3.4"},"reference-count":58,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2012,7,26]],"date-time":"2012-07-26T00:00:00Z","timestamp":1343260800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007678","name":"Institute for Research in Biomedicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007678","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001506","name":"Ministry of Science and Innovation, New Zealand","doi-asserted-by":"publisher","award":["BFU2008\u20103980"],"award-info":[{"award-number":["BFU2008\u20103980"]}],"id":[{"id":"10.13039\/501100001506","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:p>\n                    Patients with Alzheimer's disease (AD) display altered functioning of cortical networks, including altered patterns of synchronous activity and a serious deficit in cholinergic septohippocampal (SH) innervation. However, the mechanisms underlying these alterations and the implication of the GABAergic SH component in AD are largely unknown. In addition, the GABAergic septohippocampal pathway (SHP) is believed to regulate synchronous hippocampal activity by controlling the activity of interneurons. Here we show, using well\u2010characterized pathway tracing experiments, that innervation of the GABAergic SHP decreases during normal aging. Furthermore, in an AD mouse model (hAPP\n                    <jats:sub>Sw,Ind<\/jats:sub>\n                    ; J20 mice), the GABAergic SHP shows a dramatic and early onset of this decrease in 8\u2010mo\u2010old mice. This decline is not caused by neuronal loss, but by the reduced number and complexity of GABAergic SH axon terminals. Finally, we demonstrate that hippocampal \u03b8 and \u03b3 rhythm power spectra are markedly diminished in 8\u2010mo\u2010old behaving mice expressing mutated hAPP. In addition to the well\u2010known loss of cholinergic input to the hippocampus in AD, these data suggest that the altered patterns of synchronous activity seen in patients with AD could be caused by the loss of GABAergic SH axons, which modulate hippocampal network activities.\u2014Rubio, S. E., Vega\u2010Flores, G., Mart\u00ednez, A., Bosch, C., P\u00e9rez\u2010Mediavilla, A., del R\u00edo, J., Gruart, A., Delgado\u2010Garc\u00eda, J. M., Soriano, E., Pascual, M. Accelerated aging of the GABAergic septohippocampal pathway and decreased hippocampal rhythms in a mouse model of Alzheimer's disease.\n                    <jats:italic>FASEB J.<\/jats:italic>\n                    26, 4458\u20134467 (2012).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.12-208413","type":"journal-article","created":{"date-parts":[[2012,7,27]],"date-time":"2012-07-27T16:45:29Z","timestamp":1343407529000},"page":"4458-4467","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":95,"title":["Accelerated aging of the GABAergic septohippocampal pathway and decreased hippocampal rhythms in a mouse model of Alzheimer's disease"],"prefix":"10.1096","volume":"26","author":[{"given":"Sara E.","family":"Rubio","sequence":"first","affiliation":[{"name":"Developmental Neurobiology and Regeneration Laboratory Institute for Research in Biomedicine Barcelona Spain"},{"name":"Department of Cell Biology University of Barcelona Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red para Enfermedades Neurodegenerativas Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Germ\u00e1n","family":"Vega\u2010Flores","sequence":"additional","affiliation":[{"name":"Division of Neurosciences Pablo de Olavide University Seville Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Developmental Neurobiology and Regeneration Laboratory Institute for Research in Biomedicine Barcelona Spain"},{"name":"Department of Cell Biology University of Barcelona Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red para Enfermedades Neurodegenerativas Madrid 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Investigaci\u00f3n Biom\u00e9dica en Red para Enfermedades Neurodegenerativas Madrid Spain"},{"name":"Division of Neurosciences, Centro de Investigaci\u00f3n M\u00e9dica Aplicada Universidad de Navarra Pamplona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agn\u00e8s","family":"Gruart","sequence":"additional","affiliation":[{"name":"Division of Neurosciences Pablo de Olavide University Seville Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Mar\u00eda","family":"Delgado\u2010Garc\u00eda","sequence":"additional","affiliation":[{"name":"Division of Neurosciences Pablo de Olavide University Seville Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Soriano","sequence":"additional","affiliation":[{"name":"Developmental Neurobiology and Regeneration Laboratory Institute for Research in Biomedicine Barcelona Spain"},{"name":"Department of Cell Biology University of Barcelona Barcelona 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