{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T09:47:30Z","timestamp":1791020850254,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2012,8,7]],"date-time":"2012-08-07T00:00:00Z","timestamp":1344297600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:p>\n                    Nonalcoholic fatty liver disease (NAFLD) is a major health problem and a leading cause of chronic liver disease in the United States and developed countries. In humans, genetic factors greatly influence individual susceptibility to NAFLD. The goals of this study were to compare the magnitude of interindividual differences in the severity of liver injury induced by methyl\u2010donor deficiency among individual inbred strains of mice and to investigate the underlying mechanisms associated with the variability. Feeding mice a choline\u2010 and folate\u2010deficient diet for 12 wk caused liver injury similar to NAFLD. The magnitude of liver injury varied among the strains, with the order of sensitivity being A\/J \u2248 C57BL\/6J \u2248 C3H\/HeJ &lt; 129S1\/SvImJ \u2248 CAST\/EiJ &lt; PWK\/PhJ &lt; WSB\/EiJ. The interstrain variability in severity of NAFLD liver damage was associated with dysregulation of genes involved in lipid metabolism, primarily with a down\u2010regulation of the peroxisome proliferator receptor \u03b1 (PPAR\u03b1)\u2010regulated lipid catabolic pathway genes. Markers of oxidative stress and oxidative stress\u2010induced DNA damage were also elevated in the livers but were not correlated with severity of liver damage. These findings suggest that the PPAR\u03b1\u2010regulated metabolism network is one of the key mechanisms determining interstrain susceptibility and severity of NAFLD in mice.\u2014Tryndyak, V., de Conti, A., Kobets, T., Kutanzi, K., Koturbash, I., Han, T., Fuscoe, J. C., Latendresse, J. R., Melnyk, S., Shymonyak, S., Collins, L., Ross, S. A., Rusyn, I., Beland, F. A., Pogribny, I. P. Interstrain differences in the severity of liver injury induced by a choline\u2010 and folate\u2010deficient diet in mice are associated with dysregulation of genes involved in lipid metabolism.\n                    <jats:italic>FASEB J.<\/jats:italic>\n                    26, 4592\u20134602 (2012).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.12-209569","type":"journal-article","created":{"date-parts":[[2012,8,8]],"date-time":"2012-08-08T01:45:38Z","timestamp":1344390338000},"page":"4592-4602","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Interstrain differences in the severity of liver injury induced by a choline\u2010 and folate\u2010deficient diet in mice are associated with dysregulation of genes involved in lipid 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