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We also created an adipose\n                    <jats:italic>Grp78\u2010<\/jats:italic>\n                    knockout mouse utilizing the aP2 (fatty acid binding protein 4) promoter\u2010driven Cre\u2010recombinase. Adipogenesis was monitored by molecular markers and histology. Tissues were analyzed by micro\u2010CT and electron microscopy. Glucose homeostasis and cytokine analysis were performed. Our results indicate that GRP78 is essential for adipocyte differentiation\n                    <jats:italic>in vitro.<\/jats:italic>\n                    aP2\u2010cre\u2010mediated GRP78 deletion leads to lipoatrophy with ~90% reduction in gonadal and subcutaneous white adipose tissue and brown adipose tissue, severe growth retardation, and bone defects. Despite severe abnormality in adipose mass and function, adipose\n                    <jats:italic>Grp78\u2010<\/jats:italic>\n                    knockout mice showed normal plasma triglyceride levels, and plasma glucose and insulin levels were reduced by 40\u201060% compared to wild\u2010type mice, suggesting enhanced insulin sensitivity. The endoplasmic reticulum is grossly expanded in the residual mutant white adipose tissue. Thus, these studies establish that GRP78 is required for adipocyte differentiation, glucose homeostasis, and balanced secretion of adipokines. Unexpectedly, the phenotypes and metabolic parameters of the mutant mice, which showed early postnatal mortality, are uniquely distinct from previously characterized lipodystrophic mouse models.\u2014Zhu, G., Ye, R., Jung, D. Y., Barron, E., Friedline, R. H., Benoit, V. M., Hinton, D. R., Kim, J. K., Lee, A. S. GRP78 plays an essential role in adipogenesis and postnatal growth in mice.\n                    <jats:italic>FASEB J.<\/jats:italic>\n                    27, 955\u2013964 (2013).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.12-213330","type":"journal-article","created":{"date-parts":[[2012,11,24]],"date-time":"2012-11-24T21:30:06Z","timestamp":1353792606000},"page":"955-964","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["GRP78 plays an essential role in adipogenesis and postnatal growth in mice"],"prefix":"10.1096","volume":"27","author":[{"given":"Genyuan","family":"Zhu","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology University of Southern California Norris Comprehensive Cancer Center Los Angeles California 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