{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T23:20:39Z","timestamp":1784848839383,"version":"3.55.0"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,11,29]],"date-time":"2012-11-29T00:00:00Z","timestamp":1354147200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:p>\n                    Familial cholesteryl ester transfer protein (CETP) deficiency is more common in some East Asian populations than elsewhere, suggesting the possibility of a selective advantage of this genetic defect against regional infectious diseases. Historically, infection with the Asian blood fluke\n                    <jats:italic>Schistosoma japonicum<\/jats:italic>\n                    has been endemic in these regions, including Japan. We previously reported that eggs of\n                    <jats:italic>S. japonicum<\/jats:italic>\n                    require cholesteryl ester uptake from normal high\u2010density lipoprotein (HDL) but not from CETP\u2010deficient HDL for their maturation to miracidia, a critical step of the hepatic pathogenesis of schistosomiasis. Herein we show that cholesteryl ester uptake is selective from HDL, and identified CD36\u2010related protein (CD36RP) as a candidate to mediate the reaction. CD36RP was cloned from the adult and the egg developmental stages of\n                    <jats:italic>S. japonicum<\/jats:italic>\n                    , with 1880 bp encoding 506 amino acid residues exhibiting the CD36 domains and two transmembrane regions. Using antibodies against recombinant peptides representing the potential extracellular domains of CD36RP, Western blotting detected a protein with a molecular mass of 82 kDa in the particulate fraction of the adult parasite cells, which was reduced to 62 kDa after\n                    <jats:italic>N<\/jats:italic>\n                    \u2010glycanase treatment. The extracellular domain peptide bound human HDL, as established by immunoblots following nondenaturing gel electrophoresis. Antibodies against the extracellular domain suppressed HDL cholesteryl ester uptake and maturation of the eggs\n                    <jats:italic>in vitro.<\/jats:italic>\n                    CD36RP is a candidate receptor on eggs of\n                    <jats:italic>S. japonicum<\/jats:italic>\n                    that facilitates uptake of HDL cholesteryl ester necessary for egg embryonation and maturation.\u2014Okumura\u2010Noji, K., Miura, Y., Lu, R., Asai, K., Ohta, N., Brindley, P. J., Yokoyama, S. CD36\u2010related protein in\n                    <jats:italic>Schistosoma japonicum<\/jats:italic>\n                    : candidate mediator of selective cholesteryl ester uptake from high\u2010density lipoprotein for egg maturation.\n                    <jats:italic>FASEB J.<\/jats:italic>\n                    27, 1236\u20131244 (2013).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.12-219816","type":"journal-article","created":{"date-parts":[[2012,11,30]],"date-time":"2012-11-30T02:10:03Z","timestamp":1354241403000},"page":"1236-1244","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["CD36\u2010related protein in\n                    <i>Schistosoma japonicum<\/i>\n                    : candidate mediator of selective cholesteryl ester uptake from high\u2010density lipoprotein for egg maturation"],"prefix":"10.1096","volume":"27","author":[{"given":"Kuniko","family":"Okumura\u2010Noji","sequence":"first","affiliation":[{"name":"Nutritional Health Science Research Centre Chubu University Kasugai Japan"},{"name":"Department of Food and Nutritional Sciences Chubu University Kasugai Japan"},{"name":"Department of Biochemistry Nagoya City University Graduate School of Medical Sciences Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Miura","sequence":"additional","affiliation":[{"name":"Department of Neurosciences Nagoya City University Graduate School of Medical Sciences Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Lu","sequence":"additional","affiliation":[{"name":"Nutritional Health Science Research Centre Chubu University Kasugai Japan"},{"name":"Department of Food and Nutritional Sciences Chubu University Kasugai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyofumi","family":"Asai","sequence":"additional","affiliation":[{"name":"Department of Neurosciences Nagoya City University Graduate School of Medical Sciences Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuo","family":"Ohta","sequence":"additional","affiliation":[{"name":"Department of Parasitology Nagoya City University Graduate School of Medical Sciences Nagoya Japan"},{"name":"Department of Environmental Parasitology Tokyo Medical and Dental University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Brindley","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology, and Tropical Medicine School of Medicine and Health Sciences George Washington University Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Yokoyama","sequence":"additional","affiliation":[{"name":"Nutritional Health Science Research Centre Chubu University Kasugai Japan"},{"name":"Department of Food and Nutritional Sciences Chubu University Kasugai Japan"},{"name":"Department of Biochemistry Nagoya City University Graduate School of Medical Sciences Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,11,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra012396"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2004.00176.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)66457-4"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69440-3"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d2651"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)39749-2"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-6851(90)90100-Z"},{"key":"e_1_2_7_9_1","first-page":"229","article-title":"Characterization of human low density lipoprotein binding proteins on the surface of Schistosomula of Schistosoma mansoni","volume":"57","author":"Xu X.","year":"1992","journal-title":"Eur. 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