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This study aimed to investigate the role of miR\u201017\u201092 in morphogenesis and function of cardiac and smooth muscle tissues. To do so, a mouse model of conditional overexpression of miR\u201017\u201092 in cardiac and smooth muscle tissues was generated. Extensive cardiac functional studies identified a dose\u2010dependent induction of dilated, hypertrophic cardiomyopathy, and arrhythmia inducibility in transgenic animals, which correlated with premature mortality (98.3\u00b142.5 d,\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.0001). Expression analyses revealed the abundance of\n                    <jats:italic>Pten<\/jats:italic>\n                    transcript, a known miR\u201017\u201092 target, to be inversely correlated with miR\u201017\u201092 expression levels and heart size. In addition, we demonstrated through 3\u2032\u2010UTR luciferase assays and expression analyses that Connexin43 (Cx43) is a novel direct target of miR\u201019a\/b and its expression is suppressed in transgenic hearts. Taken together, these data demonstrate that dysregulated expression of miR\u201017\u201092 during cardiovascular morphogenesis results in a lethal cardiomyopathy, possibly in part through direct repression of Pten and Cx43. This study highlights the importance of miR\u201017\u201092 in both normal and pathological functions of the heart, and provides a model that may serve as a useful platform to test novel antiarrhythmic therapeutics.\u2014Danielson, L. S., Park, D. S., Rotllan, N., Chamorro\u2010Jorganes, A., Guijarro, M. V., Fernandez\u2010Hernando, C., Fishman, G. I., Phoon, C. K. L., Hernando, E. Cardiovascular dysregulation of miR\u201017\u201092 causes a lethal hypertrophic cardiomyopathy and arrhythmogenesis.\n                    <jats:italic>FASEB J.<\/jats:italic>\n                    27, 1460\u20131467 (2013).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.12-221994","type":"journal-article","created":{"date-parts":[[2012,12,27]],"date-time":"2012-12-27T21:12:22Z","timestamp":1356642742000},"page":"1460-1467","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":108,"title":["Cardiovascular dysregulation of miR\u201017\u201092 causes a lethal hypertrophic cardiomyopathy and arrhythmogenesis"],"prefix":"10.1096","volume":"27","author":[{"given":"Laura S.","family":"Danielson","sequence":"first","affiliation":[{"name":"Department of Pathology New York University School of Medicine New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Park","sequence":"additional","affiliation":[{"name":"Leon H. Charney Division of Cardiology Department of Medicine New York University School of Medicine New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noemi","family":"Rotllan","sequence":"additional","affiliation":[{"name":"Leon H. Charney Division of Cardiology Department of Medicine New York University School of Medicine New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aranzazu","family":"Chamorro\u2010Jorganes","sequence":"additional","affiliation":[{"name":"Leon H. 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