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Data from ground\u2010based animal models simulating the effects of microgravity have shown that decrements in cerebral perfusion are associated with enhanced vasoconstriction and structural remodeling of cerebral arteries. Based on these results, the purpose of this study was to test the hypothesis that 13 d of spaceflight [Space Transportation System (STS)\u2010135 shuttle mission] enhances myogenic vasoconstriction, increases medial wall thickness, and elicits no change in the mechanical properties of mouse cerebral arteries. Basilar and posterior communicating arteries (PCAs) were isolated from 9\u2010wk\u2010old female C57BL\/6 mice for\n                    <jats:italic>in vitro<\/jats:italic>\n                    vascular and mechanical testing. Contrary to that hypothesized, myogenic vasoconstrictor responses were lower and vascular distensibility greater in arteries from spaceflight group (SF) mice (\n                    <jats:italic>n<\/jats:italic>\n                    =7) relative to ground\u2010based control group (GC) mice (\n                    <jats:italic>n<\/jats:italic>\n                    =12). Basilar artery maximal diameter was greater in SF mice (SF: 236\u00b19 \u03bcm and GC: 215\u00b15 \u03bcm) with no difference in medial wall thickness (SF: 12.4\u00b11.6 \u03bcm; GC: 12.2\u00b11.2 \u03bcm). Stiffness of the PCA, as characterized\n                    <jats:italic>via<\/jats:italic>\n                    nanoindentation, was lower in SF mice (SF: 3.4\u00b10.3 N\/m; GC: 5.4\u00b10.8 N\/m). Collectively, spaceflight\u2010induced reductions in myogenic vasoconstriction and stiffness and increases in maximal diameter of cerebral arteries signify that elevations in brain blood flow may occur during spaceflight. Such changes in cerebral vascular control of perfusion could contribute to increases in intracranial pressure and an associated impairment of visual acuity in astronauts during spaceflight.\u2014Taylor, C. R., Hanna, M., Behnke, B. J., Stabley, J. N., McCullough, D. J., Davis III, R. T., Ghosh, P., Papadopoulos, A., Muller\u2010Delp, J. M., Delp, M. D. Spaceflight\u2010induced alterations in cerebral artery vasoconstrictor, mechanical, and structural properties: implications for elevated cerebral perfusion and intracranial pressure.\n                    <jats:italic>FASEB J.<\/jats:italic>\n                    27, 2282\u20132292 (2013).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.12-222687","type":"journal-article","created":{"date-parts":[[2013,3,2]],"date-time":"2013-03-02T07:15:40Z","timestamp":1362208540000},"page":"2282-2292","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":85,"title":["Spaceflight\u2010induced alterations in cerebral artery vasoconstrictor, mechanical, and structural properties: implications for elevated cerebral perfusion and intracranial pressure"],"prefix":"10.1096","volume":"27","author":[{"given":"Curtis R.","family":"Taylor","sequence":"first","affiliation":[{"name":"Department of Mechanical and Aerospace Engineering University of Florida Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mina","family":"Hanna","sequence":"additional","affiliation":[{"name":"Department of Mechanical and Aerospace Engineering University of Florida Gainesville Florida USA"},{"name":"Department of Materials Science and Engineering University of Florida Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley J.","family":"Behnke","sequence":"additional","affiliation":[{"name":"Department of Applied Physiology and Kinesiology University of Florida Gainesville Florida USA"},{"name":"Center for Exercise Science Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John N.","family":"Stabley","sequence":"additional","affiliation":[{"name":"Department of Applied Physiology and Kinesiology University of Florida Gainesville Florida USA"},{"name":"Center for Exercise Science Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle J.","family":"McCullough","sequence":"additional","affiliation":[{"name":"Department of Applied Physiology and Kinesiology University of Florida Gainesville Florida USA"},{"name":"Center for Exercise Science Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Robert T.","family":"Davis","sequence":"additional","affiliation":[{"name":"Center for Exercise Science Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Payal","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Department of Applied Physiology and Kinesiology University of Florida Gainesville Florida USA"},{"name":"Center for Exercise Science Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Papadopoulos","sequence":"additional","affiliation":[{"name":"Department of Biological Science Texas Tech University Lubbock Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judy M.","family":"Muller\u2010Delp","sequence":"additional","affiliation":[{"name":"Department of Physiology and Functional Genomics University of Florida Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Delp","sequence":"additional","affiliation":[{"name":"Department of Applied Physiology and Kinesiology University of Florida Gainesville Florida USA"},{"name":"Center for Exercise Science Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2011.06.021"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.12111986"},{"key":"e_1_2_7_4_1","unstructured":"Alexander D. 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