{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T22:09:41Z","timestamp":1791151781561,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,3,18]],"date-time":"2013-03-18T00:00:00Z","timestamp":1363564800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004794","name":"Centre National de la Recherche Scientifique","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004794","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:p>\n                    There is evidence that high\u2010density lipoproteins (HDLs) may regulate platelet function, but disparate results exist regarding the effects of oxidized HDLs on platelets. The objective of our study was to determine the role of\n                    <jats:italic>in vivo<\/jats:italic>\n                    oxidized HDLs on platelet aggregation. Platelet aggregation and redox status were investigated in 5 patients with abetalipoproteinemia (ABLP) or homozygous hypobetalipoproteinemia, two rare metabolic diseases characterized by the absence of apolipoprotein B\u2010containing lipoproteins, compared to 5 control subjects. Platelets isolated from plasma of patients with ABLP aggregated 4 to 10 times more than control platelets, depending on the agonist. By contrast, no differences in the extent of platelet aggregation were observed between ABLP platelet\u2010rich plasma (PRP) and control PRP, suggesting the presence of a protective factor in ABLP plasma. ABLP HDLs inhibited agonist\u2010induced platelet aggregation by binding to SR\u2010BI, while control HDLs had no effect. On the other hand, lipoprotein\u2010deficient plasma from patients with ABLP did not inhibit platelet aggregation. Severe oxidative stress was evidenced in patients with ABLP. Compared to control HDLs, ABLP HDLs showed a 40% decrease of \u03b1\u2010tocopherol and an 11\u2010fold increased malondialdehyde concentration. These results demonstrate that\n                    <jats:italic>in vivo<\/jats:italic>\n                    oxidized HDLs do not lose their antiaggregatory properties despite oxidation.\u2014Calzada, C., V\u00e9ricel, E., Colas, R., Guillot, N., El Khoury, G., Drai, J., Sassolas, A., Peretti, N., Ponsin, G., Lagarde, M., Moulin, P. Inhibitory effects of\n                    <jats:italic>in vivo<\/jats:italic>\n                    oxidized high\u2010density lipoproteins on platelet aggregation: evidence from patients with abetalipoproteinemia.\n                    <jats:italic>FASEB J.<\/jats:italic>\n                    27, 2855\u20132861 (2013).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.12-225169","type":"journal-article","created":{"date-parts":[[2013,3,19]],"date-time":"2013-03-19T03:17:02Z","timestamp":1363663022000},"page":"2855-2861","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Inhibitory effects of\n                    <i>in vivo<\/i>\n                    oxidized high\u2010density lipoproteins on platelet aggregation: evidence from patients with abetalipoproteinemia"],"prefix":"10.1096","volume":"27","author":[{"given":"Catherine","family":"Calzada","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Lyon Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) Unit\u00e9 Mixte de Recherche (UMR) 1060 Cardiovasculaire, M\u00e9tabolisme, Diab\u00e9tologie, et Nutrition (CarMeN) Laboratory Universit\u00e9 Lyon 1 Institut National des Sciences Appliqu\u00e9es de Lyon (INSA\u2010Lyon) Institut Multidisciplinaire de Biochimie des Lipides (IMBL) Villeurbanne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyne","family":"V\u00e9ricel","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lyon Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) Unit\u00e9 Mixte de Recherche (UMR) 1060 Cardiovasculaire, M\u00e9tabolisme, Diab\u00e9tologie, et Nutrition (CarMeN) Laboratory Universit\u00e9 Lyon 1 Institut National des Sciences Appliqu\u00e9es de Lyon (INSA\u2010Lyon) Institut Multidisciplinaire de Biochimie des Lipides (IMBL) Villeurbanne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Colas","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lyon Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) Unit\u00e9 Mixte de Recherche (UMR) 1060 Cardiovasculaire, M\u00e9tabolisme, Diab\u00e9tologie, et Nutrition (CarMeN) Laboratory Universit\u00e9 Lyon 1 Institut National des Sciences Appliqu\u00e9es de Lyon (INSA\u2010Lyon) Institut Multidisciplinaire de Biochimie des Lipides (IMBL) Villeurbanne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Guillot","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lyon Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) Unit\u00e9 Mixte de Recherche (UMR) 1060 Cardiovasculaire, M\u00e9tabolisme, Diab\u00e9tologie, et Nutrition (CarMeN) Laboratory Universit\u00e9 Lyon 1 Institut National des Sciences Appliqu\u00e9es de Lyon (INSA\u2010Lyon) Institut Multidisciplinaire de Biochimie des Lipides (IMBL) Villeurbanne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graziella","family":"El Khoury","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lyon Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) Unit\u00e9 Mixte de Recherche (UMR) 1060 Cardiovasculaire, M\u00e9tabolisme, Diab\u00e9tologie, et Nutrition (CarMeN) Laboratory Universit\u00e9 Lyon 1 Institut National des Sciences Appliqu\u00e9es de Lyon (INSA\u2010Lyon) Institut Multidisciplinaire de Biochimie des Lipides (IMBL) Villeurbanne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jocelyne","family":"Drai","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lyon Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) Unit\u00e9 Mixte de Recherche (UMR) 1060 Cardiovasculaire, M\u00e9tabolisme, Diab\u00e9tologie, et Nutrition (CarMeN) Laboratory Universit\u00e9 Lyon 1 Institut National des Sciences Appliqu\u00e9es de Lyon (INSA\u2010Lyon) Institut Multidisciplinaire de Biochimie des Lipides (IMBL) Villeurbanne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agn\u00e8s","family":"Sassolas","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lyon Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) Unit\u00e9 Mixte de Recherche (UMR) 1060 Cardiovasculaire, M\u00e9tabolisme, Diab\u00e9tologie, et Nutrition (CarMeN) Laboratory Universit\u00e9 Lyon 1 Institut National des Sciences Appliqu\u00e9es de Lyon (INSA\u2010Lyon) Institut Multidisciplinaire de Biochimie des Lipides (IMBL) Villeurbanne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"No\u00ebl","family":"Peretti","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lyon Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) Unit\u00e9 Mixte de Recherche (UMR) 1060 Cardiovasculaire, M\u00e9tabolisme, Diab\u00e9tologie, et Nutrition (CarMeN) Laboratory Universit\u00e9 Lyon 1 Institut National des Sciences Appliqu\u00e9es de Lyon (INSA\u2010Lyon) Institut Multidisciplinaire de Biochimie des Lipides (IMBL) Villeurbanne France"},{"name":"Service de Nutrition et Gastroent\u00e9rologie, Hospices Civils de Lyon Lyon Bron France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Ponsin","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lyon Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) Unit\u00e9 Mixte de Recherche (UMR) 1060 Cardiovasculaire, M\u00e9tabolisme, Diab\u00e9tologie, et Nutrition (CarMeN) Laboratory Universit\u00e9 Lyon 1 Institut National des Sciences Appliqu\u00e9es de Lyon (INSA\u2010Lyon) Institut Multidisciplinaire de Biochimie des Lipides (IMBL) Villeurbanne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Lagarde","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lyon Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) Unit\u00e9 Mixte de Recherche (UMR) 1060 Cardiovasculaire, M\u00e9tabolisme, Diab\u00e9tologie, et Nutrition (CarMeN) Laboratory Universit\u00e9 Lyon 1 Institut National des Sciences Appliqu\u00e9es de Lyon (INSA\u2010Lyon) Institut Multidisciplinaire de Biochimie des Lipides (IMBL) Villeurbanne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Moulin","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lyon Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM) 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