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Whether this is caused by a slow tissue turnover is unknown, since existing data provide diverging estimates of tendon protein half\u2010life that range from 2 mo to 200 yr. With the purpose of determining life\u2010long turnover of human tendon tissue, we used the\n                    <jats:sup>14<\/jats:sup>\n                    C bomb\u2010pulse method. This method takes advantage of the dramatic increase in atmospheric levels of\n                    <jats:sup>14<\/jats:sup>\n                    C, produced by nuclear bomb tests in 1955\u20131963, which is reflected in all living organisms. Levels of\n                    <jats:sup>14<\/jats:sup>\n                    C were measured in 28 forensic samples of Achilles tendon core and 4 skeletal muscle samples (donor birth years 1945\u20131983) with accelerator mass spectrometry (AMS) and compared to known atmospheric levels to estimate tissue turnover. We found that Achilles tendon tissue retained levels of\n                    <jats:sup>14<\/jats:sup>\n                    C corresponding to atmospheric levels several decades before tissue sampling, demonstrating a very limited tissue turnover. The tendon concentrations of\n                    <jats:sup>14<\/jats:sup>\n                    C approximately reflected the atmospheric levels present during the first 17 yr of life, indicating that the tendon core is formed during height growth and is essentially not renewed thereafter. In contrast,\n                    <jats:sup>14<\/jats:sup>\n                    C levels in muscle indicated continuous turnover. Our observation provides a fundamental premise for understanding tendon function and pathology, and likely explains the poor regenerative capacity of tendon tissue.\u2014Heinemeier, K. M., Schjerling, P., Heinemeier, J., Magnusson, S. P., Kjaer, M. Lack of tissue renewal in human adult Achilles tendon is revealed by nuclear bomb\n                    <jats:sup>14<\/jats:sup>\n                    C.\n                    <jats:italic>FASEB J.<\/jats:italic>\n                    27, 2074\u20132079 (2013).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.12-225599","type":"journal-article","created":{"date-parts":[[2013,2,11]],"date-time":"2013-02-11T22:25:58Z","timestamp":1360621558000},"page":"2074-2079","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":299,"title":["Lack of tissue renewal in human adult Achilles tendon is revealed by nuclear bomb\n                    <sup>14<\/sup>\n                    C"],"prefix":"10.1096","volume":"27","author":[{"given":"Katja Maria","family":"Heinemeier","sequence":"first","affiliation":[{"name":"Institute of Sports Medicine Department of Orthopedic Surgery M Bispebjerg Hospital University of Copenhagen Denmark"},{"name":"Center for Healthy Aging, Faculty of Health and Medical Sciences University of Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Schjerling","sequence":"additional","affiliation":[{"name":"Institute of Sports Medicine Department of Orthopedic Surgery M Bispebjerg Hospital University of Copenhagen Denmark"},{"name":"Center for Healthy Aging, Faculty of Health and Medical Sciences University of Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Heinemeier","sequence":"additional","affiliation":[{"name":"AMS <sup>14<\/sup>C Dating Centre, Department of Physics and Astronomy Aarhus University Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stig Peter","family":"Magnusson","sequence":"additional","affiliation":[{"name":"Institute of Sports Medicine Department of Orthopedic Surgery M Bispebjerg Hospital University of Copenhagen Denmark"},{"name":"Center for Healthy Aging, Faculty of Health and Medical Sciences University of Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Kjaer","sequence":"additional","affiliation":[{"name":"Institute of Sports Medicine Department of Orthopedic Surgery M Bispebjerg Hospital University of Copenhagen Denmark"},{"name":"Center for Healthy Aging, Faculty of Health and Medical Sciences University of Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,2,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.jsm.0000165347.55638.23"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncprheum0700"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.077503"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1999.00299.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00243.2005"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2005.093690"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.2007.01714.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.90361.2008"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0838.2011.01414.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.91341.2008"},{"key":"e_1_2_8_12_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0001529","article-title":"Radiocarbon dating of the human eye lens crystallines reveal proteins without carbon turnover throughout life","volume":"3","author":"Lynnerup N.","year":"2008","journal-title":"PLoS ONE"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.146.3648.1170"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033822200041163"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/437333a"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.04.028"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.03.030"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033822200041990"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033822200003672"},{"key":"e_1_2_8_20_1","first-page":"1","article-title":"2000 CDC growth charts for the United States: methods and development","volume":"11","author":"Department of Health and Human Services.","year":"2000","journal-title":"Vital. 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