{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T16:01:08Z","timestamp":1770825668136,"version":"3.50.1"},"reference-count":57,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2013,4,29]],"date-time":"2013-04-29T00:00:00Z","timestamp":1367193600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:p>\n                    Nonsegmental vitiligo (NSV) is characterized by loss of inherited skin color. The cause of the disease is still unknown despite accumulating\n                    <jats:italic>in vivo<\/jats:italic>\n                    and\n                    <jats:italic>in vitro<\/jats:italic>\n                    evidence of massive epidermal oxidative stress\n                    <jats:italic>via<\/jats:italic>\n                    H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    and peroxynitrite (ONOO\n                    <jats:sup>\u2013<\/jats:sup>\n                    ) in affected individuals. The most favored hypothesis is based on autoimmune mechanisms. Strictly segmental vitiligo (SSV) with dermatomal distribution is a rare entity, often associated with stable outcome. Recently, it was documented that this form can be associated with NSV (mixed vitiligo). We here asked the question whether ROS and possibly ONOO\n                    <jats:sup>\u2013<\/jats:sup>\n                    could be players in the pathogenesis of SSV. Our\n                    <jats:italic>in situ<\/jats:italic>\n                    results demonstrate for the first time epidermal biopterin accumulation together with significantly decreased epidermal catalase, thioredoxin\/thioreoxin reductase, and MSRA\/MSRB expression. Moreover, we show epidermal ONOO\n                    <jats:sup>\u2013<\/jats:sup>\n                    accumulation.\n                    <jats:italic>In vivo<\/jats:italic>\n                    FT\u2010Raman spectroscopy reveals the presence of H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    , methionine sulfoxide, and tryptophan metabolites;\n                    <jats:italic>i.e., N<\/jats:italic>\n                    \u2010formylkynurenine and kynurenine, implying Fenton chemistry in the cascade (\n                    <jats:italic>n<\/jats:italic>\n                    = 10). Validation of the basic data stems from successful repigmentation of skin and eyelashes in affected individuals, regardless of SSV or segmental vitiligo in association with NSV after reduction of epidermal H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    (\n                    <jats:italic>n<\/jats:italic>\n                    =5). Taken together, our contribution strongly supports H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    \/ONOO\u2010mediated stress in the pathogenesis of SSV. Our findings offer new treatment intervention for lost skin and hair color.\u2014Schallreuter, K. U., Salem, M. A. E. L., Holtz, S., Panske, A., Basic evidence for epidermal H2O2\/ONOO\u2013\u2010mediated oxidation\/nitration in segmental vitiligo is supported by repigmentation of skin and eyelashes after reduction of epidermal H2O2 with topical NB\u2010UVB\u2010activated pseudocatalase PC\u2010KUS. FASEB J. 27, 3113\u20133122 (2013).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.12-226779","type":"journal-article","created":{"date-parts":[[2013,4,30]],"date-time":"2013-04-30T00:30:26Z","timestamp":1367281826000},"page":"3113-3122","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Basic evidence for epidermal H\n                    <sub>2<\/sub>\n                    O\n                    <sub>2<\/sub>\n                    \/ONOO\n                    <sup>\u2013<\/sup>\n                    \u2010mediated oxidation\/nitration in segmental vitiligo is supported by repigmentation of skin and eyelashes after reduction of epidermal H\n                    <sub>2<\/sub>\n                    O\n                    <sub>2<\/sub>\n                    with topical NB\u2010UVB\u2010activated pseudocatalase PC\u2010KUS"],"prefix":"10.1096","volume":"27","author":[{"given":"Karin U.","family":"Schallreuter","sequence":"first","affiliation":[{"name":"Institute for Pigmentary Disorders E. M. Arndt University Greifswald Germany"},{"name":"Centre of Skin Sciences School of Life Sciences University of Bradford Bradford U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed A. E. L.","family":"Salem","sequence":"additional","affiliation":[{"name":"Institute for Pigmentary Disorders E. M. Arndt University Greifswald Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Holtz","sequence":"additional","affiliation":[{"name":"Institute for Pigmentary Disorders E. M. Arndt University Greifswald Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Panske","sequence":"additional","affiliation":[{"name":"Institute for Pigmentary Disorders E. M. 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