{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T06:53:41Z","timestamp":1775976821651,"version":"3.50.1"},"reference-count":117,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,4,22]],"date-time":"2013-04-22T00:00:00Z","timestamp":1366588800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:p>\n                    The lentiviruses, human and feline immunodeficiency viruses (HIV\u20101 and FIV, respectively), infect the brain and cause neurovirulence, evident as neuronal injury, inflammation, and neurobehavioral abnormalities with diminished survival. Herein, different lentivirus infections in conjunction with neural cell viability were investigated, concentrating on type 1 interferon\u2010regulated pathways. Transcriptomic network analyses showed a preponderance of genes involved in type 1 interferon signaling, which was verified by increased expression of the type 1 interferon\u2010associated genes,\n                    <jats:italic>Mx1<\/jats:italic>\n                    and\n                    <jats:italic>CD317<\/jats:italic>\n                    , in brains from HIV\u2010infected persons (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.05). Leukocytes infected with different strains of FIV or HIV\u20101 showed differential\n                    <jats:italic>Mx1<\/jats:italic>\n                    and\n                    <jats:italic>CD317<\/jats:italic>\n                    expression (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.05).\n                    <jats:italic>In vivo<\/jats:italic>\n                    studies of animals infected with the FIV strains, FIV\n                    <jats:sub>ch<\/jats:sub>\n                    or FIV\n                    <jats:sub>ncsu<\/jats:sub>\n                    , revealed that FIV\n                    <jats:sub>ch<\/jats:sub>\n                    \u2010infected animals displayed deficits in memory and motor speed compared with the FIV\n                    <jats:sub>ncsu<\/jats:sub>\n                    \u2010 and mock\u2010infected groups (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.05).\n                    <jats:italic>TNF\u2010\u03b1, IL\u20101\u03b2<\/jats:italic>\n                    , and\n                    <jats:italic>CD40<\/jats:italic>\n                    expression was increased in the brains of FIV\n                    <jats:sub>ch<\/jats:sub>\n                    \u2010infected animals; conversely,\n                    <jats:italic>Mx1<\/jats:italic>\n                    and\n                    <jats:italic>CD317<\/jats:italic>\n                    transcript levels were increased in the brains of FIV\n                    <jats:sub>ncsu<\/jats:sub>\n                    \u2010infected animals, principally in microglia (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.05). Gliosis and neuronal loss were evident among FIV\n                    <jats:sub>ch<\/jats:sub>\n                    \u2010infected animals compared with mock\u2010 and FIV\n                    <jats:sub>ncsu<\/jats:sub>\n                    \u2010infected animals (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.05). Lentiviral infections induce type 1 interferon\u2010regulated gene expression in microglia in a viral diversity\u2010dependent manner, representing a mechanism by which immune responses might be exploited to limit neurovirulence.\u2014Polyak, M. J., Vivithanaporn, P., Maingat, F. G., Walsh, J. G., Branton, W., Cohen, E. A., Meeker, R., Power, C. Differential type 1 interferon\u2010regulated gene expression in the brain during AIDS: interactions with viral diversity and neurovirulence.\n                    <jats:italic>FASEB J.<\/jats:italic>\n                    27, 2829\u20102844 (2013).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.13-227868","type":"journal-article","created":{"date-parts":[[2013,4,23]],"date-time":"2013-04-23T04:31:36Z","timestamp":1366691496000},"page":"2829-2844","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Differential type 1 interferon\u2010regulated gene expression in the brain during AIDS: interactions with viral diversity and neurovirulence"],"prefix":"10.1096","volume":"27","author":[{"given":"Maria J.","family":"Polyak","sequence":"first","affiliation":[{"name":"Department of Medicine University of Alberta Edmonton Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pornpun","family":"Vivithanaporn","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Faculty of Science Mahidol University Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ferdinand G.","family":"Maingat","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Alberta Edmonton Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John G.","family":"Walsh","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Alberta Edmonton Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Branton","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Alberta Edmonton Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric A.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Institut de Recherches Cliniques de Montr\u00e9al Universit\u00e9 de Montr\u00e9al Montreal Quebec Canada"},{"name":"Department of Microbiology and Immunology Universit\u00e9 de Montr\u00e9al Montreal Quebec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rick","family":"Meeker","sequence":"additional","affiliation":[{"name":"Department of Neurology University of North Carolina Durham North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Power","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Alberta Edmonton Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,4,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.9.1.100"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2174\/157016206777709410"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(00)01737-9"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1527"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1214935"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181f4d5bb"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0b013e32834695fb"},{"key":"e_1_2_7_9_1","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.coviro.2011.10.008","article-title":"Interferon\u2010stimulated genes and their antiviral effector functions","volume":"1","author":"Schoggins J. 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